Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | high concentrations of cofactor increases type I activity | Rattus sp. | |
additional information | hypothyroidism enhances type II activity and decreases type I activity | Rattus sp. | |
reduced thiols | - |
Rattus sp. |
Cloned (Comment) | Organism |
---|---|
transcription in vitro, translation in Xenopus laevis oocytes | Rattus sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-Propyl-2-thiouracil | inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity | Rattus sp. | |
ipanoic acid | - |
Rattus sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
3,3',5'-triiodothyronine | type I | Rattus sp. | |
0.1 | - |
3,3',5'-triiodothyronine | DTT 20 mM | Rattus sp. |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus sp. | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodothyronine + AH2 | Rattus sp. | isoenzyme type I | 3,3'-diiodothyronine + iodide + A + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus sp. | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | type II, outer ring (phenolic) deiodination | Rattus sp. | |
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | type I, outer ring (phenolic) deiodination | Rattus sp. |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | thyronine 5'-deiodinase type II | Rattus sp. | - |
brown adipose tissue | thyronine 5'-deiodinase type II | Rattus sp. | - |
glial cell | thyronine 5'-deiodinase type II | Rattus sp. | - |
hypophysis | thyronine 5'-deiodinase type II | Rattus sp. | - |
kidney | thyronine 5'-deiodinase type I | Rattus sp. | - |
liver | thyronine 5'-deiodinase type I | Rattus sp. | - |
thyroid gland | thyronine 5'-deiodinase type I | Rattus sp. | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodothyronine + AH2 | isoenzyme type I | Rattus sp. | 3,3'-diiodothyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
iodothyronine 5'-deiodinase | type II, no selenoprotein, induced by bt2cAMP and hydrocortisone (ED50 4nM) | Rattus sp. |
iodothyronine 5'-deiodinase | type I, selenoprotein, inducible by T3 (higher synthesis) and angiotensin II (positive chronotropic effect in myocard) | Rattus sp. |
iodothyronine 5'-deiodinase | isoenzymes type I (D1) and type II (D2) | Rattus sp. |