Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.21.99.4 extracted from

  • Auf'mkolk, M.; Koehrle, J.; Hesch, R.D.; Cody, V.
    Inhibition of rat liver iodothyronine deiodinase. Interaction of aurones with the iodothyronine ligand-binding site (1986), J. Biol. Chem., 261, 11623-11630.
    View publication on PubMed
Search for more literature for 1.21.99.4

Inhibitors

Inhibitors Comment Organism Structure
(2E)-2-(3,4-dihydroxybenzylidene)-4,6-dihydroxy-1-benzofuran-3(2H)-one aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11 Rattus norvegicus
(2E)-2-(3,4-dihydroxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11 Rattus norvegicus
(2E)-4,6-dihydroxy-2-(4-hydroxy-3-iodobenzylidene)-1-benzofuran-3(2H)-one aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11 Rattus norvegicus
(2E)-4,6-dihydroxy-2-(4-hydroxybenzylidene)-1-benzofuran-3(2H)-one aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11 Rattus norvegicus
(4-[(E)-(4,6-dihydroxy-3-oxo-1-benzofuran-2(3H)-ylidene)methyl]phenoxy)acetic acid aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11 Rattus norvegicus
2-(3,4-dihydroxybenzyl)-4,6-dihydroxy-1-benzofuran-3(2H)-one aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5'-triiodo-L-thyronine + AH2
-
 Rattus norvegicus 3,3'-diiodothyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2
-
 Rattus norvegicus 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0005
-
 pH 7.4, 37°C Rattus norvegicus (2E)-4,6-dihydroxy-2-(4-hydroxy-3-iodobenzylidene)-1-benzofuran-3(2H)-one
0.001
-
 pH 7.4, 37°C Rattus norvegicus (2E)-2-(3,4-dihydroxybenzylidene)-4,6-dihydroxy-1-benzofuran-3(2H)-one
0.001
-
 pH 7.4, 37°C Rattus norvegicus (2E)-4,6-dihydroxy-2-(4-hydroxybenzylidene)-1-benzofuran-3(2H)-one
0.005
-
 pH 7.4, 37°C Rattus norvegicus (4-[(E)-(4,6-dihydroxy-3-oxo-1-benzofuran-2(3H)-ylidene)methyl]phenoxy)acetic acid
0.008
-
 pH 7.4, 37°C Rattus norvegicus 2-(3,4-dihydroxybenzyl)-4,6-dihydroxy-1-benzofuran-3(2H)-one
0.01
-
 pH 7.4, 37°C Rattus norvegicus (2E)-2-(3,4-dihydroxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one