Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.21.99.3 extracted from

  • Ng, L.; Lyubarsky, A.; Nikonov, S.S.; Ma, M.; Srinivas, M.; Kefas, B.; St Germain, D.L.; Hernandez, A.; Pugh, E.N.; Forrest, D.
    Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors (2010), J. Neurosci., 30, 3347-3357.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.21.99.3

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-thyroxine + AH2 Mus musculus
-
 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retina
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,5,3'-triiodo-L-thyronine + AH2
-
 Mus musculus 3,3'-diiodothyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2
-
 Mus musculus 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Synonyms

Synonyms Comment Organism
Dio3
-
 Mus musculus
type 3 deiodinase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
dithiothreitol
-
 Mus musculus

General Information

General Information Comment Organism
malfunction in Dio3-deficient mice, about 80% of both M opsin+ and S opsin+ cones are lost through neonatal cell death Mus musculus
physiological function the development of cones, the photoreceptors for daylight and color vision, requires protection from thyroid hormone by type 3 deiodinase Mus musculus