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Literature summary for 1.21.99.3 extracted from

  • Dentice, M.; Luongo, C.; Huang, S.; Ambrosio, R.; Elefante, A.; Mirebeau-Prunier, D.; Zavacki, A.M.; Fenzi, G.; Grachtchouk, M.; Hutchin, M.; Dlugosz, A.A.; Bianco, A.C.; Missero, C.; Larsen, P.R.; Salvatore, D.
    Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes (2007), Proc. Natl. Acad. Sci. USA, 104, 14466-14471.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.21.99.3

Application

Application Comment Organism
medicine sonic hedgehog pathway plays a critical role in hair follicle physiology and is constitutively active in basal cell carcinomas, induces D3 in proliferating keratinocytes and in BCCs through Gli2, reversing this T3 deficiency may be a therapeutic approach for BCCs and perhaps other D3-expressing tumors Homo sapiens
medicine sonic hedgehog pathway plays a critical role in hair follicle physiology and is constitutively active in basal cell carcinomas, induces TYPE 3 DEIODINASE in proliferating keratinocytes and in BCCs through Gli2, reversing this T3 deficiency may be a therapeutic approach for BCCs and perhaps other TYPE 3 DEIODINASE-expressing tumors Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of RNAi to knock down D3 in transient transfection experiments using G2N2C, Tb3A, and wild type keratinocytes Homo sapiens
expression of RNAi to knock down type 3 deiodinase in transient transfection experiments using G2N2C, Tb3A, and wild type keratinocytes Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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 3-week-old Swiss CD1 female mice
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Source Tissue

Source Tissue Comment Organism Textmining
basal cell carcinoma cell
-
 Homo sapiens
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basal cell carcinoma cell wild type, G2N2C and Tb3A transgenic BCC cell lines expressing Gli2 under the control of the keratin 5 promoter Mus musculus
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HaCaT cell human keratinocyte cell line Homo sapiens
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hair follicle
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 Mus musculus
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skin
-
 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5'-triiodo-L-thyronine + AH2 D3 terminates thyroid hormone action by by inactivating T3 Homo sapiens 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
3,3',5'-triiodo-L-thyronine + AH2 type 3 deiodinase terminates thyroid hormone action by inactivating T3 Mus musculus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?

Synonyms

Synonyms Comment Organism
D3
-
 Homo sapiens
thyroxine 5-deiodinase
-
 Mus musculus
thyroxine 5-deiodinase
-
 Homo sapiens
type 3 deiodinase
-
 Homo sapiens
type 3 deiodinase D3 Mus musculus