Application | Comment | Organism |
---|---|---|
medicine | sonic hedgehog pathway plays a critical role in hair follicle physiology and is constitutively active in basal cell carcinomas, induces D3 in proliferating keratinocytes and in BCCs through Gli2, reversing this T3 deficiency may be a therapeutic approach for BCCs and perhaps other D3-expressing tumors | Homo sapiens |
medicine | sonic hedgehog pathway plays a critical role in hair follicle physiology and is constitutively active in basal cell carcinomas, induces TYPE 3 DEIODINASE in proliferating keratinocytes and in BCCs through Gli2, reversing this T3 deficiency may be a therapeutic approach for BCCs and perhaps other TYPE 3 DEIODINASE-expressing tumors | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expression of RNAi to knock down D3 in transient transfection experiments using G2N2C, Tb3A, and wild type keratinocytes | Homo sapiens |
expression of RNAi to knock down type 3 deiodinase in transient transfection experiments using G2N2C, Tb3A, and wild type keratinocytes | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
3-week-old Swiss CD1 female mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
basal cell carcinoma cell | - |
Homo sapiens | - |
basal cell carcinoma cell | wild type, G2N2C and Tb3A transgenic BCC cell lines expressing Gli2 under the control of the keratin 5 promoter | Mus musculus | - |
HaCaT cell | human keratinocyte cell line | Homo sapiens | - |
hair follicle | - |
Mus musculus | - |
skin | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodo-L-thyronine + AH2 | D3 terminates thyroid hormone action by by inactivating T3 | Homo sapiens | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
3,3',5'-triiodo-L-thyronine + AH2 | type 3 deiodinase terminates thyroid hormone action by inactivating T3 | Mus musculus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
D3 | - |
Homo sapiens |
thyroxine 5-deiodinase | - |
Mus musculus |
thyroxine 5-deiodinase | - |
Homo sapiens |
type 3 deiodinase | - |
Homo sapiens |
type 3 deiodinase | D3 | Mus musculus |