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Literature summary for 1.21.3.7 extracted from

  • Taura, F.
    Studies on tetrahydrocannabinolic acid synthase that produces the acidic precursor of tetrahydrocannabinol, the pharmacologically active cannabinoid in marijuana (2009), Drug Discov. Ther., 3, 83-87.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed using a baculovirus insect expression system and expressed in transgenic Nicotiana tabacum hairy roots and methylotrophic yeast Pichia pastoris Cannabis sativa

Metals/Ions

Metals/Ions Comment Organism Structure
additional information the enzyme does not require any metal ions for activity Cannabis sativa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
76000
-
about 76000 Da, gel filtration Cannabis sativa

Organism

Organism UniProt Comment Textmining
Cannabis sativa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DE-52 column chromatography, phenyl Sepharose CL-4B column chromatography, and hydroxylapatite column chromatography Cannabis sativa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cannabigerolate + O2 maximum conversion rate of about 98% in 24 h Cannabis sativa DELTA9-tetrahydrocannabinolate + H2O2
-
?

Subunits

Subunits Comment Organism
monomer 1 * about 75000, SDS-PAGE Cannabis sativa

Synonyms

Synonyms Comment Organism
THCA synthase
-
Cannabis sativa

Cofactor

Cofactor Comment Organism Structure
FAD the enzyme contains covalently attached FAD at a molar ratio of FAD to protein of 1:1 Cannabis sativa
additional information the enzyme does not require any cofactors or coenzymes Cannabis sativa

General Information

General Information Comment Organism
metabolism key enzyme in the synthesis of tetrahydrocannabinolate Cannabis sativa