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Literature summary for 1.21.3.1 extracted from

  • Loke, P.; Sim, T.S.
    Analysis of glutamines in catalysis in Cephalosporium acremonium isopenicillin N synthase by site-directed mutagenesis (1998), Biochem. Biophys. Res. Commun., 252, 472-475.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
O2 required Acremonium chrysogenum

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of recombinant enzyme mutants in Cephalosporium acremonium Acremonium chrysogenum

Protein Variants

Protein Variants Comment Organism
Q227L site-directed mutagenesis, 55.10% remaining activity compared to wild-type Acremonium chrysogenum
Q337L site-directed mutagenesis, slightly reduced activity compared to wild-type Acremonium chrysogenum

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Acremonium chrysogenum 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
Acremonium chrysogenum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Acremonium chrysogenum common step in the biosynthesis of penicillins, cephalosporins and cephamycins isopenicillin N + 2 H2O
-
?

Organism

Organism UniProt Comment Textmining
Acremonium chrysogenum
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000027
-
wild-type Acremonium chrysogenum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
Acremonium chrysogenum isopenicillin N + 2 H2O
-
?
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 common step in the biosynthesis of penicillins, cephalosporins and cephamycins Acremonium chrysogenum isopenicillin N + 2 H2O
-
?

Synonyms

Synonyms Comment Organism
IPNS
-
Acremonium chrysogenum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
26
-
assay at Acremonium chrysogenum