Application | Comment | Organism |
---|---|---|
additional information | target for disruption of thyroid hormone homeostasis by environmental halogenated chemicals | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2',3,4',5,6'-pentachlorobiphenyl-4-ol | - |
Homo sapiens | |
2',3,4',6'-tetrachlorobiphenyl-4-ol | - |
Homo sapiens | |
2,2',5,5'-tetrachlorobiphenyl-4-ol | - |
Homo sapiens | |
2,3,6-tribromo-4-(2,4-dibromophenoxy)phenol | - |
Homo sapiens | |
2,3-dibromo-4-(2,4-dibromophenoxy)phenol | - |
Homo sapiens | |
2,5-dibromo-4-(2,4-dibromophenoxy)phenol | - |
Homo sapiens | |
3-bromo-4-(2,4-dibromophenoxy)phenol | - |
Homo sapiens | |
3-hydroxy-2,2',5,5'-tetrachlorobiphenyl | - |
Homo sapiens | |
4,4'-dihydroxy-3,3',5,5'-tetrachlorobiphenyl | - |
Homo sapiens | |
5-bromo-2-(2,4-dibromophenoxy)phenol | - |
Homo sapiens | |
5-bromo-2-(4-bromophenoxy)phenol | - |
Homo sapiens | |
benzbromarone | - |
Homo sapiens | |
bithionol | - |
Homo sapiens | |
bromoxynil | - |
Homo sapiens | |
closantel | - |
Homo sapiens | |
erythrosine B | - |
Homo sapiens | |
additional information | target for disruption of thyroid hormone homeostasis by environmental halogenated chemicals, e.g. food colorants, pharmaceuticals, agrochemicals, and antiparasitics, effects of environmental halogenated chemicals on iodotyrosine deiodinase activity, overview. Non-hydroxylated PCBs (e.g., 2,2',4,4'-tetrachlorobiphenyl) and PBDEs (e.g., 2,2',4,4'-tetrabromodiphenyl ether), nitrofen, trichlabendazole, miconazole and amiodarone lack IYD-inhibitory activity | Homo sapiens | |
nitroxynil | - |
Homo sapiens | |
oxyclozanide | - |
Homo sapiens | |
phloxine B | - |
Homo sapiens | |
Rose bengal | - |
Homo sapiens | |
tribromsalan | - |
Homo sapiens | |
triclosan | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + 2 NADP+ + 2 iodide | Homo sapiens | - |
3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6PHW0 | gene DEHAL1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
thyroid gland | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + 2 NADP+ + 2 iodide | - |
Homo sapiens | 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ | - |
r | |
additional information | the enzyme can act as a general dehalogenase, promoting reductive dehalogenation of 3-bromo- and 3-chloro-L-tyrosine, though not 3-fluoro-L-tyrosine | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IYD | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FMN | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | thyroid dysfunction can have very serious consequences, including mental retardation | Homo sapiens |
physiological function | a FMN moiety that is involved in reduced NADPH-dependent reductive deiodination of 3-iodo-Ltyrosine (MIT) and 3,5-diiodo-L-tyrosine (DIT), which are released along with the thyroid hormones T4 and T3 during thyroglobulin proteolysis. Iodotyrosine deiodinase is involved in iodide salvage by catalyzing deiodination of iodinated by-products of thyroid hormone production. Thyroid hormones play important roles in growth, development, differentiation, and basal metabolic homeostasis, as well as in brain development in human fetus and children | Homo sapiens |