Activating Compound | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Bos taurus | |
FMN | - |
Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,5-diiodo-L-tyrosine | pronounced substrate inhibition above 5 microM | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
thyroid gland | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,5-diiodo-L-tyrosine + dithionite | solubilized enzyme preparations are active with dithionite, but not with NADPH. Particle-bound enzyme uses both dithionite and NADPH. At concentrations of substrate below 1 microM, 3,5-diiodo-L-tyrosine is more rapidly deiodinated than 3-iodo-L-tyrosine, which is reversed at concentrations greater than 5 microM | Bos taurus | 3-iodo-L-tyrosine + ? + I- | - |
? | |
3,5-diiodo-L-tyrosine + NADPH + H+ | solubilized enzyme preparations are active with dithionite, but not with NADPH. Particle-bound enzyme uses both dithionite and NADPH. At concentrations of substrate below 1 microM, 3,5-diiodo-L-tyrosine is more rapidly deiodinated than 3-iodo-L-tyrosine, which is reversed at concentrations greater than 5 microM | Bos taurus | 3-iodo-L-tyrosine + NADP+ + I- | - |
? |