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Literature summary for 1.20.4.1 extracted from

  • Gregus, Z.; Nemeti, B.
    The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase works as an arsenate reductase in human red blood cells and rat liver cytosol (2005), Toxicol. Sci., 85, 859-869.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ADP moderate Homo sapiens
ADP moderate Rattus norvegicus
ATP moderate Homo sapiens
ATP moderate Rattus norvegicus
Koningic acid inhibition of both classical enzymic and arsentate reductase activities of glyceraldehyde-3-phosphate dehydrogenase Homo sapiens
Koningic acid inhibition of both classical enzymic and arsentate reductase activities of glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus
NADH strong Homo sapiens
NADH strong Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol besides glyceraldehyde-3-phosphate dehydrogenase, presence of other enzymes contributing to arsenate reduction Rattus norvegicus 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
glyceraldehyde-3-phosphate dehydrogenase working as arsenate reductase
-
Rattus norvegicus
-
glyceraldehyde-3-phosphate dehydrogenase working as arsenate reductase
-

Reaction

Reaction Comment Organism Reaction ID
arsenate + glutathione + glutaredoxin = arsenite + a glutaredoxin-glutathione disulfide + H2O arsenate reduction by glyceraldehyde-3-phosphate dehydrogenase may take place during or as a consequence of, the arsenolytic cleavage of the thioester bond formed between the enzyme’s C149 and the 3-phosphoglycerol moiety of the substrate Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arsenate + reduced glutathione + NAD+ + glyceraldehyde-3-phosphate
-
Homo sapiens arsenite + glutathione + ?
-
?
arsenate + reduced glutathione + NAD+ + glyceraldehyde-3-phosphate
-
Rattus norvegicus arsenite + glutathione + ?
-
?