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BRENDA support

Literature summary for 1.2.4.4 extracted from

  • Mersey, B.D.; Jin, P.; Danner, D.J.
    Human microRNA (miR29b) expression controls the amount of branched chain alpha-ketoacid dehydrogenase complex in a cell (2005), Hum. Mol. Genet., 14, 3371-3377.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
alpha-Chloroisocaproate
-
Homo sapiens

Application

Application Comment Organism
additional information use of a microRNA to exert control on a metabolic pathway of amino acid catabolism Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
microRNA 29a total BCKD activity decreases over a 6-day period following a single transfection Homo sapiens
microRNA 29b total BCKD activity decreases over a 6-day period following a single transfection, is targeted to the mRNA for the dihydrolipoamide branched chain acyltransferase component of BCKD and prevents translation when bound Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
BCKD
-
Homo sapiens
branched chain alpha-ketoacid dehydrogenase complex
-
Homo sapiens