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Literature summary for 1.2.4.4 extracted from
- A second branched-chain alpha-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermectins (1995), J. Bacteriol., 177, 3504-3511.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| thiamine diphosphate | - |
Streptomyces avermitilis |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Streptomyces avermitilis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Streptomyces avermitilis | the enzyme catalyzes a reaction of branched-chain amino acid catabolism which constitutes a crucial step to provide fatty acid precursors for antibiotic biosynthesis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces avermitilis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme catalyzes a reaction of branched-chain amino acid catabolism which constitutes a crucial step to provide fatty acid precursors for antibiotic biosynthesis | Streptomyces avermitilis | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | MW of the alpha subunit of the E1 component is 44394 Da, determined by SDS-PAGE | Streptomyces avermitilis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| CoA | - |
Streptomyces avermitilis | |
| NAD+ | - |
Streptomyces avermitilis | |
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