Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ADP | activates the enzyme complex for production of reactive oxygen species in absence of NAD+ | Rattus norvegicus | |
carbonyl cyanide p-trifluoromethoxyphenylhydrazone | activates the enzyme complex for production of reactive oxygen species in absence of NAD+ | Rattus norvegicus | |
rotenone | stimulates H2O2 production | Mus musculus | |
rotenone | stimulates H2O2 production | Rattus norvegicus | |
thiamine diphosphate | exogenous | Mus musculus | |
thiamine diphosphate | exogenous | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knock-out mice, deficient in dihydrolipoyl dehydrogenase, show reduced 2-oxoglutarate dehydrogenase activity and reduced H2O2 production | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial inner membrane | - |
Mus musculus | 5743 | - |
mitochondrial inner membrane | - |
Rattus norvegicus | 5743 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Mus musculus | |
Ca2+ | - |
Rattus norvegicus | |
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | Mus musculus | - |
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | Rattus norvegicus | - |
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
additional information | Mus musculus | enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview | ? | - |
? | |
additional information | Rattus norvegicus | enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
wild-type mice, and knock-out mice deficient in dihydrolipoyl dehydrogenase | - |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Mus musculus | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Rattus norvegicus | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
additional information | enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview | Mus musculus | ? | - |
? | |
additional information | enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-ketoglutarate dehydrogenase multienzyme complex | - |
Mus musculus |
alpha-ketoglutarate dehydrogenase multienzyme complex | - |
Rattus norvegicus |
KGDHC | - |
Mus musculus |
KGDHC | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at, H2O2 production | Mus musculus |
37 | - |
assay at, H2O2 production | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
7.4 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mus musculus | |
NAD+ | - |
Rattus norvegicus | |
thiamine diphosphate | - |
Mus musculus | |
thiamine diphosphate | - |
Rattus norvegicus |