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Literature summary for 1.2.4.2 extracted from

  • Tretter, L.; Adam-Vizi, V.
    Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase (2004), J. Neurosci., 24, 7771-7778.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
ADP
-
Sus scrofa
NADH stimulates H2O2 production reaction of the enzyme Cavia porcellus
NADH stimulates H2O2 production reaction of the enzyme Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
H2O2
-
Cavia porcellus
H2O2
-
Sus scrofa
NAD+ inhibits H2O2 production reaction of the enzyme Cavia porcellus
NAD+ inhibits H2O2 production reaction of the enzyme Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Cavia porcellus 5739
-
mitochondrion
-
Sus scrofa 5739
-
synaptosome
-
Cavia porcellus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates both catalytic function and H2O2 production Cavia porcellus
Ca2+ activates both catalytic function and H2O2 production Sus scrofa
Mg2+
-
Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine Cavia porcellus
-
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine Sus scrofa
-
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir
additional information Sus scrofa enzyme also catalyzes the production of H2O2 from 2-oxoglutarate with CoA in absence of NAD+, which inhibits this reaction, enzyme is a target for reactive oxygen species and also contributes to generation of oxidative stress in mitochondria when NADH oxidation is impaired, overview ?
-
?
additional information Cavia porcellus enzyme also catalyzes the production of H2O2 in vivo, in vitro, and in situ from 2-oxoglutarate with CoA in absence of NAD+, which inhibits this reaction, enzyme is a atrget for reactive oxygen species and also contributes to generation of oxidative stress in mitochondria when NADH oxidation is impaired, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
enzyme is further purified from commercial pig heart preparation Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
Cavia porcellus
-
commercial preparation from heart Sus scrofa
-
heart
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Sus scrofa
additional information
-
activity under different conditions in synaptosomes Cavia porcellus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + CoA
-
Cavia porcellus ? + H2O2
-
?
2-oxoglutarate + CoA
-
Sus scrofa ? + H2O2
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
Cavia porcellus [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
Sus scrofa [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir
additional information enzyme also catalyzes the production of H2O2 from 2-oxoglutarate with CoA in absence of NAD+, which inhibits this reaction, enzyme is a target for reactive oxygen species and also contributes to generation of oxidative stress in mitochondria when NADH oxidation is impaired, overview Sus scrofa ?
-
?
additional information enzyme also catalyzes the production of H2O2 in vivo, in vitro, and in situ from 2-oxoglutarate with CoA in absence of NAD+, which inhibits this reaction, enzyme is a atrget for reactive oxygen species and also contributes to generation of oxidative stress in mitochondria when NADH oxidation is impaired, overview Cavia porcellus ?
-
?

Synonyms

Synonyms Comment Organism
alpha-ketoglutarate dehydrogenase
-
Cavia porcellus
alpha-ketoglutarate dehydrogenase
-
Sus scrofa
alpha-KGDH
-
Cavia porcellus
alpha-KGDH
-
Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Sus scrofa
37
-
assay at, synaptosomes Cavia porcellus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Sus scrofa
7.4
-
assay at, synaptosomes Cavia porcellus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Cavia porcellus
NAD+
-
Sus scrofa
thiamine diphosphate
-
Cavia porcellus
thiamine diphosphate
-
Sus scrofa