Cloned (Comment) | Organism |
---|---|
expression in Escheirchia coli | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0004 | - |
4-(dimethylamino)cinnamaldehyde | pH 8, 37°C | Mus musculus | |
0.0005 | - |
4-(dimethylamino)cinnamaldehyde | pH 8, 37°C | Mus musculus | |
0.0008 | - |
4-(dimethylamino)cinnamaldehyde | pH 8, 37°C | Mus musculus | |
0.0023 | - |
Vanillin | pH 8, 37°C | Mus musculus | |
0.0033 | - |
4-(dimethylamino)cinnamaldehyde | pH 8, 37°C | Mus musculus | |
0.0035 | - |
Salicylaldehyde | pH 8, 37°C | Mus musculus | |
0.0046 | - |
Vanillin | pH 8, 37°C | Mus musculus | |
0.0054 | - |
Vanillin | pH 8, 37°C | Mus musculus | |
0.0094 | - |
N1-methylnicotinamide | pH 8, 37°C | Mus musculus | |
0.0126 | - |
retinalaldehyde | pH 8, 37°C | Mus musculus | |
0.0132 | - |
Salicylaldehyde | pH 8, 37°C | Mus musculus | |
0.0165 | - |
retinalaldehyde | pH 8, 37°C | Mus musculus | |
0.0211 | - |
Salicylaldehyde | pH 8, 37°C | Mus musculus | |
0.0264 | - |
retinalaldehyde | pH 8, 37°C | Mus musculus | |
0.0279 | - |
N1-methylnicotinamide | pH 8, 37°C | Mus musculus | |
0.0321 | - |
retinalaldehyde | pH 8, 37°C | Mus musculus | |
0.0896 | - |
Salicylaldehyde | pH 8, 37°C | Mus musculus | |
0.104 | - |
Vanillin | pH 8, 37°C | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | G3X982 | isoform Aox3 | - |
Mus musculus | O54754 | isoform AOX1 | - |
Mus musculus | Q3TYQ9 | isoform AOX4 | - |
Mus musculus | Q5SGK3 | isoform AOX2 | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme, simplified two-step purification method using Ni-NTA and size-exclusion chromatography | Mus musculus |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.146 | - |
substrate salicylaldehyde, pH 8, 37°C, after chemical sulfuration of the molybdopterin cofactor | Mus musculus |
0.158 | - |
substrate salicylaldehyde, pH 8, 37°C, after chemical sulfuration of the molybdopterin cofactor | Mus musculus |
0.585 | - |
substrate salicylaldehyde, pH 8, 37°C, after chemical sulfuration of the molybdopterin cofactor | Mus musculus |
0.88 | - |
substrate salicylaldehyde, pH 8, 37°C, after chemical sulfuration of the molybdopterin cofactor | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-(dimethylamino)cinnamaldehyde + H2O + O2 | - |
Mus musculus | 4-(dimethylamino)cinnamic acid + H2O2 | - |
? | |
additional information | no substrate for isoform AOX2: pyridoxal | Mus musculus | ? | - |
- |
|
additional information | no substrate for isoform AOX3: pyridoxal | Mus musculus | ? | - |
- |
|
additional information | no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal | Mus musculus | ? | - |
- |
|
additional information | no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal | Mus musculus | ? | - |
- |
|
N1-methylnicotinamide + H2O + O2 | - |
Mus musculus | N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2 | - |
? | |
retinalaldehyde + O2 + H2O | - |
Mus musculus | retinoic acid + H2O2 | - |
? | |
salicylaldehyde + H2O + O2 | - |
Mus musculus | salicylic acid + H2O2 | - |
? | |
vanillin + H2O + O2 | - |
Mus musculus | vanillic acid + H2O2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 150000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
AOX1 | - |
Mus musculus |
AOX2 | - |
Mus musculus |
AOX3 | - |
Mus musculus |
AOX4 | - |
Mus musculus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.18 | - |
retinalaldehyde | pH 8, 37°C | Mus musculus | |
0.26 | - |
Vanillin | pH 8, 37°C | Mus musculus | |
0.33 | - |
N1-methylnicotinamide | pH 8, 37°C | Mus musculus | |
0.47 | - |
retinalaldehyde | pH 8, 37°C | Mus musculus | |
0.51 | - |
4-(dimethylamino)cinnamaldehyde | pH 8, 37°C | Mus musculus | |
0.75 | - |
4-(dimethylamino)cinnamaldehyde | pH 8, 37°C | Mus musculus | |
0.82 | - |
N1-methylnicotinamide | pH 8, 37°C | Mus musculus | |
1.34 | - |
Vanillin | pH 8, 37°C | Mus musculus | |
1.47 | - |
4-(dimethylamino)cinnamaldehyde | pH 8, 37°C | Mus musculus | |
1.94 | - |
4-(dimethylamino)cinnamaldehyde | pH 8, 37°C | Mus musculus | |
2.05 | - |
retinalaldehyde | pH 8, 37°C | Mus musculus | |
2.29 | - |
Salicylaldehyde | pH 8, 37°C | Mus musculus | |
2.66 | - |
Vanillin | pH 8, 37°C | Mus musculus | |
3.42 | - |
Salicylaldehyde | pH 8, 37°C | Mus musculus | |
3.55 | - |
Salicylaldehyde | pH 8, 37°C | Mus musculus | |
3.7 | - |
Salicylaldehyde | pH 8, 37°C | Mus musculus | |
7.5 | - |
Vanillin | pH 8, 37°C | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
molybdenum cofactor | purified enzyme displays molybdenum saturation levels around 40% | Mus musculus | |
molybdenum cofactor | purified enzyme displays molybdenum saturation levels around 50% | Mus musculus | |
[2Fe-2S]-center | purified enzyme displays iron saturation levels around 60% | Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | AOX2 is the isoform generating the largest rate of superoxide radicals of around 40% in relation to moles of substrate converted | Mus musculus |
physiological function | isoform AOX1 is the homolog to the human enzyme and produces a rate of approximately 30% of superoxide radicals in relation to moles of substrate converted | Mus musculus |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
11.7 | - |
N1-methylnicotinamide | pH 8, 37°C | Mus musculus | |
13.3 | - |
retinalaldehyde | pH 8, 37°C | Mus musculus | |
18.3 | - |
retinalaldehyde | pH 8, 37°C | Mus musculus | |
25 | - |
Salicylaldehyde | pH 8, 37°C | Mus musculus | |
48.3 | - |
Vanillin | pH 8, 37°C | Mus musculus | |
71.7 | - |
Vanillin | pH 8, 37°C | Mus musculus | |
87.7 | - |
N1-methylnicotinamide | pH 8, 37°C | Mus musculus | |
123.3 | - |
retinalaldehyde | pH 8, 37°C | Mus musculus | |
175 | - |
Salicylaldehyde | pH 8, 37°C | Mus musculus | |
260 | - |
Salicylaldehyde | pH 8, 37°C | Mus musculus | |
568.3 | - |
4-(dimethylamino)cinnamaldehyde | pH 8, 37°C | Mus musculus | |
575 | - |
Vanillin | pH 8, 37°C | Mus musculus | |
605 | - |
4-(dimethylamino)cinnamaldehyde | pH 8, 37°C | Mus musculus | |
701.7 | - |
Vanillin | pH 8, 37°C | Mus musculus | |
1006.7 | - |
Salicylaldehyde | pH 8, 37°C | Mus musculus | |
2088.3 | - |
4-(dimethylamino)cinnamaldehyde | pH 8, 37°C | Mus musculus | |
3278.3 | - |
4-(dimethylamino)cinnamaldehyde | pH 8, 37°C | Mus musculus |