Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.3.1 extracted from

  • Dalvie, D.; Zhang, C.; Chen, W.; Smolarek, T.; Obach, R.S.; Loi, C.M.
    Cross-species comparison of the metabolism and excretion of zoniporide: contribution of aldehyde oxidase to interspecies differences (2010), Drug Metab. Dispos., 38, 641-654.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
menadione specific inhibitor of aldehyde oxidase Homo sapiens
raloxifene specific inhibitor of aldehyde oxidase, complete inhibition at 0.01 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0034
-
zoniporide in 25 mM phosphate buffer at 37°C, pH not specified in the publication Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
zoniporide + H2O + O2 i.e. 1-(quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl guanidine Homo sapiens 2-oxozoniporide + H2O2
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0098
-
in 25 mM phosphate buffer at 37°C, pH not specified in the publication Homo sapiens menadione
12
-
in 25 mM phosphate buffer at 37°C, pH not specified in the publication Homo sapiens raloxifene