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Literature summary for 1.2.3.1 extracted from

  • Torres, R.A.; Korzekwa, K.R.; McMasters, D.R.; Fandozzi, C.M.; Jones, J.P.
    Use of density functional calculations to predict the regioselectivity of drugs and molecules metabolized by aldehyde oxidase (2007), J. Med. Chem., 50, 4642-4647.
    View publication on PubMed

Application

Application Comment Organism
degradation the enzyme plays a dual role in the metabolism of physiologically important endogenous compounds and the biotransformation of xenobiotics. Simple qualitative method using density functional theory to predict the product of aldehyde oxidase metabolism by examining the energetics of likely tetrahedral intermediates resulting from nucleophilic attack on carbon synthetic construct

Organism

Organism UniProt Comment Textmining
synthetic construct
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzaldehyde + H2O + O2
-
synthetic construct benzoic acid + H2O2
-
?
additional information oxidation of substrates by aldehyde oxidase appears to be due primarily to the electronic effects of the substituents synthetic construct ?
-
?
phthalazine + H2O + O2
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synthetic construct 1-phthalazinone + H2O2
-
?