Application | Comment | Organism |
---|---|---|
medicine | aldehyde oxidase activity in rats estimated on the basis of benzaldehyde, N1-methylnicotinamide and methotrexate oxidase activities rapidly increases from birth, reaching a plateau within 4 weeks, and is regulated by expression of the protein. Aldehyde oxidase plays an important role in metabolizing many drugs that may be administered to pediatric patients. Developmental changes are important for the clinical application in infants of methotrexate and other drugs that are detoxified by aldehyde oxidase | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sea:SD rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | postnatal day 1, 7 and 14 rats show little or no liver aldehyde oxidase activity. Activity is markedly increased in liver cytosol from rats after postnatal day 14 and is then maintained up to 6 weeks | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzaldehyde + H2O + O2 | - |
Rattus norvegicus | benzoate + H2O2 | - |
? | |
methotrexate + H2O + O2 | - |
Rattus norvegicus | 7-hydroxymethotrexate + H2O2 | - |
? | |
N1-methylnicotinamide + H2O + O2 | - |
Rattus norvegicus | N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2 | - |
? |