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Literature summary for 1.2.3.1 extracted from

  • Sasaki, T.; Masubuchi, A.; Yamamura, M.; Watanabe, N.; Hiratsuka, M.; Mizugaki, M.; Itoh, K.; Tanaka, Y.
    Rat strain differences in stereospecific 2-oxidation of RS-8359, a reversible and selective MAO-A inhibitor, by aldehyde oxidase (2006), Biopharm. Drug Dispos., 27, 247-255.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0804
-
(S)-RS-8359 pH 7.4, 37°C, enzyme from Wistar-Imamichi strain, ratio Vmax/Km 1.98 microl per min and mg Rattus norvegicus
0.0813
-
(S)-RS-8359 pH 7.4, 37°C, enzyme from Jcl:Wistar strain, ratio Vmax/Km 1.00 microl per min and mg Rattus norvegicus
0.0833
-
(S)-RS-8359 pH 7.4, 37°C, enzyme from Crj:Wistar strain, ratio Vmax/Km 1.46 microl per min and mg Rattus norvegicus
0.1046
-
(S)-RS-8359 pH 7.4, 37°C, enzyme from LEW:Crj strain, ratio Vmax/Km 0.58 microl per min and mg Rattus norvegicus
0.14
-
(S)-RS-8359 pH 7.4, 37°C, enzyme from F344/DuCrj strain, ratio Vmax/Km 0.01 microl per min and mg Rattus norvegicus
0.17
-
(S)-RS-8359 pH 7.4, 37°C, enzyme from Slc:SD strain, ratio Vmax/Km 0.09 microl per min and mg Rattus norvegicus
0.173
-
(S)-RS-8359 pH 7.4, 37°C, enzyme from Crj:SD strain, ratio Vmax/Km 0.06 microl per min and mg Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q9Z0U5 study on ten different strains
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-RS-8359 + H2O + O2 i.e. 4-([(7S)-7-hydroxy-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]amino)benzonitrile, reversible inhibitor of monoamine oxidase A. Remarkable strain differences in activity on substrate, correlating in part with expressed levels of protein Rattus norvegicus 2-keto-(S)-RS-8359 + H2O2
-
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