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Literature summary for 1.2.3.1 extracted from

  • Neumeier, M.; Weigert, J.; Schaeffler, A.; Weiss, T.S.; Schmidl, C.; Buettner, R.; Bollheimer, C.; Aslanidis, C.; Schoelmerich, J.; Buechler, C.
    Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro (2006), Biochem. Biophys. Res. Commun., 350, 731-735.
    View publication on PubMed

Application

Application Comment Organism
medicine adiponectin and fenobibric acid reduce enzyme isoform AOX1 by activating peroxisome proliferator-activated receptor alpha whereas fatty liver disease is associated with elevated hepatic AOX1 level Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary hepatocyte Rattus norvegicus
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liver induction of enzyme by high-fat diet, but not by free fatty acids or leptin Rattus norvegicus
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