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Literature summary for 1.2.1.95 extracted from

  • Hijarrubia, M.J.; Aparicio, J.F.; Martin, J.F.
    Domain structure characterization of the multifunctional alpha-aminoadipate reductase from Penicillium chrysogenum by limited proteolysis. Activation of alpha-aminoadipate does not require the peptidyl carrier protein box or the reduction domain (2003), J. Biol. Chem., 278, 8250-8256.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
EDTA 5 mM, 75% inhibition Penicillium chrysogenum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.16
-
NADPH pH 9.0, 30°C Penicillium chrysogenum
1.3
-
ATP pH 9.0, 30°C Penicillium chrysogenum
1.4
-
L-2-aminoadipate pH 9.0, 30°C Penicillium chrysogenum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ absolutely required for activity, optimal concentration 10 mM Penicillium chrysogenum
Mn2+ can partly replace Mg2+, leading to 60% of maximum activity with Mg2+ Penicillium chrysogenum
additional information no activity with Ca2+, Co2+, Hg2+, Cu2+ Penicillium chrysogenum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
154800
-
1 * 155000, SDS-PAGE, 1 * 154800, calculated Penicillium chrysogenum
155000
-
1 * 155000, SDS-PAGE, 1 * 154800, calculated Penicillium chrysogenum
171000
-
gel filtration Penicillium chrysogenum

Organism

Organism UniProt Comment Textmining
Penicillium chrysogenum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Penicillium chrysogenum

Storage Stability

Storage Stability Organism
-20°C, stable Penicillium chrysogenum
4°C, stable Penicillium chrysogenum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-2-aminoadipate + NADPH + H+ + ATP
-
Penicillium chrysogenum (S)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate
-
?
additional information no substrates: adipic acid, DL-diaminopimelic acid, L-glutamate Penicillium chrysogenum ?
-
?
S-carboxymethyl-L-cysteine + NADPH + H+ + ATP 20fold lower activity than with L-2-aminoadipate Penicillium chrysogenum ? + NADP+ + AMP + diphosphate
-
?

Subunits

Subunits Comment Organism
monomer 1 * 155000, SDS-PAGE, 1 * 154800, calculated Penicillium chrysogenum

Synonyms

Synonyms Comment Organism
alpha-AAR
-
Penicillium chrysogenum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25 29
-
Penicillium chrysogenum

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
30
-
rapid loss of activity above Penicillium chrysogenum

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
30
-
1h, 20% loss of activity Penicillium chrysogenum
37
-
15 min, 50% loss of activity Penicillium chrysogenum

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1
-
L-2-aminoadipate pH 9.0, 30°C Penicillium chrysogenum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
Penicillium chrysogenum

pH Range

pH Minimum pH Maximum Comment Organism
7.5 9.5
-
Penicillium chrysogenum