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Literature summary for 1.2.1.83 extracted from

  • Qiu, J.; Ma, Y.; Wen, Y.; Chen, L.; Wu, L.; Liu, W.
    Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine (2012), Appl. Environ. Microbiol., 78, 2154-2160.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Pseudomonas sp.

Organism

Organism UniProt Comment Textmining
Pseudomonas sp. H8ZPX2
-
-
Pseudomonas sp. HZN6 H8ZPX2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O
-
 Pseudomonas sp. 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+
-
 ?
4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O
-
 Pseudomonas sp. HZN6 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
ALD
-
 Pseudomonas sp.
SapD
-
 Pseudomonas sp.

Cofactor

Cofactor Comment Organism Structure
additional information no cofactor: NAD+ Pseudomonas sp.
NADP+ specific for NADP+ Pseudomonas sp.

General Information

General Information Comment Organism
physiological function an enzyme deletion strain is still able to grow on pseudoxynicotine, the cell growth and the rate of pseudoxynicotine removal are initially slightly reduced. After the deletion strain is cultured with pseudoxynicotine for several generations, the pseudoxynicotine degradation characteristics reach the wild-type level Pseudomonas sp.