Literature summary for 1.2.1.8 extracted from

Munoz-Clares, R.A.; Diaz-Sanchez, A.G.; Gonzalez-Segura, L.; Montiel, C.
Kinetic and structural features of betaine aldehyde dehydrogenases: Mechanistic and regulatory implications (2010), Arch. Biochem. Biophys., 493, 71-81.

Search for more literature for 1.2.1.8

Inhibitors

Inhibitors	Comment	Organism	Structure
NAD+	substrate inhibition by high concentrations of NAD+	Pseudomonas aeruginosa

Metals/Ions

Metals/Ions	Comment	Organism	Structure
K+	-	Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
betaine aldehyde + NAD(P)+ + H2O	Pseudomonas aeruginosa	-	glycine betaine + NAD(P)H + H+	-	ir

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	Q9HTJ1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-aminopropionaldehyde + NAD(P)+ + H2O	-	Pseudomonas aeruginosa	?	-	?
3-dimethylsulfoniopropionaldehyde + NAD(P)+ + H2O	-	Pseudomonas aeruginosa	?	-	?
4-N-trimethylaminobutyraldehyde + NAD(P)+ + H2O	-	Pseudomonas aeruginosa	?	-	?
betaine aldehyde + NAD(P)+ + H2O	-	Pseudomonas aeruginosa	glycine betaine + NAD(P)H + H+	-	ir
gamma-aminobutyraldehyde + NAD(P)+ + H2O	-	Pseudomonas aeruginosa	?	-	?
additional information	BADH can also use as substrates aminoaldehydes and other quaternary ammonium and tertiary sulfonium compounds, thereby participating in polyamine catabolism and in the synthesis of gamma-aminobutyrate, carnitine, and 3-dimethylsulfoniopropionate	Pseudomonas aeruginosa	?	-	?

Subunits

Subunits	Comment	Organism
homodimer	-	Pseudomonas aeruginosa

Synonyms

Synonyms	Comment	Organism
BADH	-	Pseudomonas aeruginosa
betaine aldehyde dehydrogenase	-	Pseudomonas aeruginosa
betaine aldehyde:NAD(P)+ oxidoreductase	-	Pseudomonas aeruginosa
PaBADH	-	Pseudomonas aeruginosa

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Pseudomonas aeruginosa
NADP+	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)