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Literature summary for 1.2.1.8 extracted from

  • Gruez, A.; Roig-Zamboni, V.; Grisel, S.; Salomoni, A.; Valencia, C.; Campanacci, V.; Tegoni, M.; Cambillau, C.
    Crystal structure and kinetics identify Escherichia coli YdcW gene product as a medium-chain aldehyde dehydrogenase (2004), J. Mol. Biol., 343, 29-41.
    View publication on PubMed
Search for more literature for 1.2.1.8

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop method Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0025
-
 NAD+ pH 7.7, reaction with benzaldehyde Escherichia coli
0.004
-
 NAD+ pH 7.7, reaction with isovaleraldehyde Escherichia coli
0.009
-
 NAD+ pH 7.7, reaction with undecanal Escherichia coli
0.012
-
 NAD+ pH 7.7, reaction with valeraldehyde Escherichia coli
0.05
-
 NAD+ pH 7.7, reaction with phenyl acetaldehyde Escherichia coli
0.08
-
 NADP+ pH 7.7, reaction with undecanal Escherichia coli
0.1
-
 benzaldehyde pH 7.7, coenzyme NAD+ Escherichia coli
0.2
-
 Valeraldehyde pH 7.7, coenzyme NAD+ Escherichia coli
0.2
-
 Isovaleraldehyde pH 7.7, coenzyme NAD+ Escherichia coli
0.27
-
 NADP+ pH 7.7, reaction with valeraldehyde Escherichia coli
0.31
-
 NADP+ pH 7.7, reaction with isovaleraldehyde Escherichia coli
0.5
-
 Butyraldehyde pH 7.7, coenzyme NAD+ Escherichia coli
0.5
-
 p-nitrobenzaldehyde pH 7.7, coenzyme NAD+ Escherichia coli
0.61
-
 NADP+ pH 7.7, reaction with phenyl acetaldehyde Escherichia coli
0.8
-
 propionaldehyde pH 7.7, coenzyme NAD+ Escherichia coli
0.8
-
 NAD+ pH 7.7, reaction with p-nitrobenzaldehyde Escherichia coli
1
-
 NADP+ pH 7.7, reaction with p-nitrobenzaldehyde Escherichia coli
1.4
-
 NADP+ pH 7.7, reaction with benzaldehyde Escherichia coli
1.8
-
 Betaine aldehyde pH 7.7, coenzyme NADP+ Escherichia coli
2 3 Undecanal pH 7.7, coenzyme NADP+ Escherichia coli
2.5
-
 methylglyoxal pH 7.7, coenzyme NAD+ Escherichia coli
3.4
-
 Butyraldehyde pH 7.7, coenzyme NADP+ Escherichia coli
3.6
-
 acetaldehyde pH 7.7, coenzyme NAD+ Escherichia coli
3.8
-
 formaldehyde pH 7.7, coenzyme NAD+ Escherichia coli
4.1
-
 Valeraldehyde pH 7.7, coenzyme NADP+ Escherichia coli
4.3
-
 glycolaldehyde pH 7.7, coenzyme NAD+ Escherichia coli
6.5
-
 Betaine aldehyde pH 7.7, coenzyme NAD+ Escherichia coli
6.7
-
 benzaldehyde pH 7.7, coenzyme NADP+ Escherichia coli
9
-
 methylglyoxal pH 7.7, coenzyme NADP+ Escherichia coli
11
-
 D,L-glyceraldehyde pH 7.7, coenzyme NADP+ Escherichia coli
11.5
-
 glycolaldehyde pH 7.7, coenzyme NADP+ Escherichia coli
15
-
 Isovaleraldehyde pH 7.7, coenzyme NADP+ Escherichia coli
21
-
 propionaldehyde pH 7.7, coenzyme NADP+ Escherichia coli
28
-
 acetaldehyde pH 7.7, coenzyme NADP+ Escherichia coli
48
-
 D,L-glyceraldehyde pH 7.7, coenzyme NAD+ Escherichia coli
51
-
 phenyl acetaldehyde pH 7.7, coenzyme NADP+ Escherichia coli
106
-
 Undecanal pH 7.7, coenzyme NAD+ Escherichia coli
140
-
 phenyl acetaldehyde pH 7.7, coenzyme NAD+ Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NAD+ + H2O
-
 Escherichia coli acetate + NADH + H+
-
 ?
acetaldehyde + NADP+ + H2O
-
 Escherichia coli acetate + NADPH + H+
-
 ?
benzaldehyde + NAD+ + H2O
-
 Escherichia coli benzoate + NADH + H+
-
 ?
benzaldehyde + NADP+ + H2O
-
 Escherichia coli benzoate + NADPH + H+
-
 ?
betaine aldehyde + NAD+ + H2O more active on medium-chain aldehydes than on betaine aldehyde Escherichia coli betaine + NADH + H+
-
 ?
betaine aldehyde + NADP+ + H2O more active on medium-chain aldehydes than on betaine aldehyde Escherichia coli betaine + NADPH + H+
-
 ?
butyraldehyde + NAD+ + H2O
-
 Escherichia coli butyrate + NADH + H+
-
 ?
butyraldehyde + NADP+ + H2O
-
 Escherichia coli butyrate + NADPH + H+
-
 ?
DL-glyceraldehyde + NAD+ + H2O
-
 Escherichia coli glycerate + NADH + H+
-
 ?
DL-glyceraldehyde + NADP+ + H2O
-
 Escherichia coli glycerate + NADPH + H+
-
 ?
formaldehyde + NAD+ + H2O
-
 Escherichia coli formate + NADH + H+
-
 ?
formaldehyde + NADP+ + H2O
-
 Escherichia coli formate + NADPH + H+
-
 ?
glycolaldehyde + NAD+ + H2O
-
 Escherichia coli glycolate + NADH + H+
-
 ?
glycolaldehyde + NADP+ + H2O
-
 Escherichia coli glycolate + NADPH + H+
-
 ?
isovaleraldehyde + NAD+ + H2O
-
 Escherichia coli isovalerate + NADH + H+
-
 ?
isovaleraldehyde + NADP+ + H2O
-
 Escherichia coli isovalerate + NADPH + H+
-
 ?
methylglyoxal + NAD+ + H2O
-
 Escherichia coli pyruvate + NADH + H+
-
 ?
methylglyoxal + NADP+ + H2O
-
 Escherichia coli ? + NADPH + H+
-
 ?
p-nitrobenzaldehyde + NAD+ + H2O
-
 Escherichia coli p-nitrobenzoate + NADH + H+
-
 ?
p-nitrobenzaldehyde + NADP+ + H2O
-
 Escherichia coli p-nitrobenzoate + NADPH + H+
-
 ?
phenyl acetaldehyde + NAD+ + H2O
-
 Escherichia coli phenyl acetate + NADH + H+
-
 ?
phenyl acetaldehyde + NADP+ + H2O
-
 Escherichia coli phenyl acetate + NADPH + H+
-
 ?
propionaldehyde + NAD+ + H2O
-
 Escherichia coli propionate + NADH + H+
-
 ?
propionaldehyde + NADP+ + H2O
-
 Escherichia coli propionate + NADPH + H+
-
 ?
undecanal + NAD+ + H2O
-
 Escherichia coli undecanoate + NADH + H+
-
 ?
undecanal + NADP+ + H2O
-
 Escherichia coli undecanoate + NADPH + H+
-
 ?
valeraldehyde + NAD+ + H2O
-
 Escherichia coli valerate + NADH + H+
-
 ?
valeraldehyde + NADP+ + H2O
-
 Escherichia coli valerate + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
YdcW
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NAD+ much better affinity for NAD+ than for NADP+ Escherichia coli
NADP+ much better affinity for NAD+ than for NADP+ Escherichia coli