Literature summary for 1.2.1.5 extracted from

Zhou, S.; Catherine, C.; Rathnasingh, C.; Somasundar, A.; Park, S.
Production of 3-hydroxypropionic acid from glycerol by recombinant Pseudomonas denitrificans (2013), Biotechnol. Bioeng., 110, 3177-3187.

Search for more literature for 1.2.1.5

Application

Application	Comment	Organism
synthesis	titer and yield of 3-hydroxypropionic acid are improved to 54.7 mmol/l and 67% (mol/mol), respectively, when an ALDH gene (puuC) from Klebsiella pneumoniae is overexpressed in Pseudomonas denitrificans strain ATCC 13867	Klebsiella pneumoniae

Organism

Organism	UniProt	Comment	Textmining
Klebsiella pneumoniae	-	-	-
Klebsiella pneumoniae DSM 2026	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
1.48	-	recombinant enzyme, using 3-hydroxypropionaldehyde and NAD+ as substrates, at pH 8.0 and 37°C	Klebsiella pneumoniae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-hydroxypropionaldehyde + NAD+ + H2O	-	Klebsiella pneumoniae	3-hydroxypropanoate + NADH + 2 H+	-	?
3-hydroxypropionaldehyde + NAD+ + H2O	-	Klebsiella pneumoniae DSM 2026	3-hydroxypropanoate + NADH + 2 H+	-	?

Synonyms

Synonyms	Comment	Organism
ALDH	-	Klebsiella pneumoniae
NAD(P)(+)-dependent aldehyde dehydrogenase	-	Klebsiella pneumoniae
PuuC	-	Klebsiella pneumoniae

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Klebsiella pneumoniae
NADP+	-	Klebsiella pneumoniae

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Release 2023.1 (January 2023)