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Literature summary for 1.2.1.5 extracted from

  • Ho, K.K.; Mukhopadhyay, A.; Li, Y.F.; Mukhopadhyay, S.; Weiner, H.
    A point mutation produced a class 3 aldehyde dehydrogenase with increased protective ability against the killing effect of cyclophosphamide (2008), Biochem. Pharmacol., 76, 690-696.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.5

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
T186S the mutant has increased activity against aldehyde and decreased activity against smaller substrates like benzaldehyde compared to the native enzyme and cells transformed with the point mutant are better protected against the killing effect of cyclophosphamides Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P30838
-
-

Purification (Commentary)

Purification (Comment) Organism
nickel affinity column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
stomach
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NADP+ + H2O
-
 Homo sapiens acetate + NADPH + H+
-
 ?
mafosfamide + NADP+ + H2O
-
 Homo sapiens ?
-
 ?
p-hydroxybenzaldehyde + NADP+ + H2O
-
 Homo sapiens p-hydroxybenzoic acid + NADPH + H+
-
 ?
p-nitrobenzaldehyde + NADP+ + H2O
-
 Homo sapiens p-nitrobenzoate + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
ALDH3
-
 Homo sapiens
class 3 aldehyde dehydrogenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Homo sapiens