Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Chloral hydrate | 50% inhibition of isoenzyme F1 by 0.25 mM, 50% inhibition of isoenzyme F2 by 0.4 mM | Equus caballus | |
Disulfiram | - |
Equus caballus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0001 | - |
pentanal | isoenzyme F1 | Equus caballus | |
0.0002 | - |
acetaldehyde | isoenzyme F2 | Equus caballus | |
0.0003 | - |
phenylacetaldehyde | isoenzyme F2 | Equus caballus | |
0.0005 | - |
isopentanal | isoenzyme F1 | Equus caballus | |
0.003 | - |
NAD+ | isoenzyme F1 | Equus caballus | |
0.003 | - |
NAD+ | reaction with acetaldehyde | Equus caballus | |
0.004 | - |
phenylacetaldehyde | isoenzyme F1 | Equus caballus | |
0.005 | - |
propanal | isoenzyme F1 | Equus caballus | |
0.01 | - |
NADP+ | isoenzyme F2 | Equus caballus | |
0.01 | - |
Chloroacetaldehyde | isoenzyme F2 | Equus caballus | |
0.01 | - |
NADP+ | reaction with acetaldehyde | Equus caballus | |
0.03 | - |
NAD+ | isoenzyme F2 | Equus caballus | |
0.03 | - |
Chloroacetaldehyde | isoenzyme F1 | Equus caballus | |
0.03 | - |
NAD+ | reaction with acetaldehyde | Equus caballus | |
0.05 | - |
glycolaldehyde | isoenzyme F2 | Equus caballus | |
0.07 | - |
acetaldehyde | isoenzyme F1 | Equus caballus | |
0.13 | - |
glycolaldehyde | isoenzyme F1 | Equus caballus | |
0.27 | - |
formaldehyde | isoenzyme F2 | Equus caballus | |
0.7 | - |
NADP+ | isoenzyme F1 | Equus caballus | |
0.7 | - |
NADP+ | reaction with acetaldehyde | Equus caballus | |
0.94 | - |
formaldehyde | isoenzyme F1 | Equus caballus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
52000 | - |
4 * 52000, isoenzyme F1, SDS-PAGE | Equus caballus |
53000 | - |
4 * 53000, isoenzyme F2, SDS-PAGE | Equus caballus |
230000 | - |
isoenzyme F1, non-denaturing PAGE | Equus caballus |
240000 | - |
isoenzyme F2, non-denaturing PAGE | Equus caballus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Equus caballus | isoenzyme f1 may be the primary enzyme for oxidizing the acetaldehyde produced during ethanol oxidation in vivo | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Equus caballus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
isoenzyme F1 and F2 | Equus caballus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Equus caballus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.35 | - |
isoenzyme F1 | Equus caballus |
0.8 | - |
- |
Equus caballus |
1 | - |
isoenzyme F2 | Equus caballus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetaldehyde + NAD+ + H2O | - |
Equus caballus | acetate + NADH + H+ | - |
? | |
acetaldehyde + NADP+ + H2O | - |
Equus caballus | acetate + NADPH + H+ | - |
? | |
benzaldehyde + NAD+ + H2O | - |
Equus caballus | benzoate + NADH + H+ | - |
? | |
chloroacetaldehyde + NAD+ + H2O | - |
Equus caballus | chloroacetate + NADH + H+ | - |
? | |
cinnamaldehyde + NAD+ + H2O | - |
Equus caballus | cinnamate + NADH + H+ | - |
? | |
formaldehyde + NAD+ + H2O | - |
Equus caballus | formate + NADH + H+ | - |
? | |
glycolaldehyde + NADP+ + H2O | - |
Equus caballus | glycolate + NADPH + H+ | - |
? | |
isopentanal + NAD+ + H2O | - |
Equus caballus | isopentanoate + NADH + H+ | - |
? | |
additional information | isoenzyme f1 may be the primary enzyme for oxidizing the acetaldehyde produced during ethanol oxidation in vivo | Equus caballus | ? | - |
? | |
n-pentanal + NAD+ + H2O | - |
Equus caballus | n-pentanoate + NADH + H+ | - |
? | |
phenylacetaldehyde + NAD+ + H2O | - |
Equus caballus | phenylacetate + NADH + H+ | - |
? | |
propanal + NAD+ + H2O | - |
Equus caballus | propionate + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 52000, isoenzyme F1, SDS-PAGE | Equus caballus |
tetramer | 4 * 53000, isoenzyme F2, SDS-PAGE | Equus caballus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | relative but not absolute specificity for NAD+ over NADP+ | Equus caballus |