Any feedback?
Literature summary for 1.2.1.5 extracted from
- Purification and characterization of aldehyde dehydrogenase from rat liver mitochondria (1988), Arch. Biochem. Biophys., 262, 211-220.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Chloral hydrate | - |
Rattus norvegicus |  |
| Disulfiram | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
4 * 60000, SDS-PAGE | Rattus norvegicus |
| 240000 | - |
sucrose density gradient centrifugation | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.212 | - |
activity with NADP+ | Rattus norvegicus |
| 0.378 | - |
activity with NAD+ | Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 0-1°C, stable for 1 week | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetaldehyde + 3-pyridine aldehyde adenine dinucleotide phosphate | - |
Rattus norvegicus | acetate + ? | - |
? | |
| acetaldehyde + acetylpyridine adenine dinucleotide | - |
Rattus norvegicus | acetate + ? | - |
? | |
| acetaldehyde + deamino-NAD+ + H2O | - |
Rattus norvegicus | acetate + deamino-NADH + H+ | - |
? | |
| acetaldehyde + NAD+ + H2O | - |
Rattus norvegicus | acetate + NADH + H+ | - |
? | |
| acetaldehyde + NADP+ + H2O | - |
Rattus norvegicus | acetate + NADPH + H+ | - |
? | |
| acetaldehyde + thio-NAD+ + H2O | - |
Rattus norvegicus | acetate + thio-NADH + H+ | - |
? | |
| acetaldehyde + thio-NADP+ | - |
Rattus norvegicus | acetate + ? | - |
? | |
| formaldehyde + NAD+ + H2O | - |
Rattus norvegicus | formate + NADH + H+ | - |
? | |
| formaldehyde + NADP+ + H2O | - |
Rattus norvegicus | formate + NADPH + H+ | - |
? | |
| n-butanal + NAD+ + H2O | - |
Rattus norvegicus | butanoate + NADH + H+ | - |
? | |
| n-pentanal + NAD+ + H2O | - |
Rattus norvegicus | n-pentanoate + NADH + H+ | - |
? | |
| propanal + NAD+ + H2O | - |
Rattus norvegicus | propionate + NADH + H+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 60000, SDS-PAGE | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 55 | - |
20 min, complete inactivation | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.4 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.2 | 6.7 | pH 6.2: about 80% of maximal activity, pH 6.7: about 80% of maximal activity | Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.012 | - |
Disulfiram | with respect to NADP+ | Rattus norvegicus | |
| 0.069 | - |
Disulfiram | with respect to NAD+ | Rattus norvegicus | |
| 0.19 | - |
Chloral hydrate | with respect to NAD+ | Rattus norvegicus | |
| 0.2 | - |
Chloral hydrate | with respect to NADP+ | Rattus norvegicus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
