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Literature summary for 1.2.1.5 extracted from
- Purification and properties of murine corneal aldehyde dehydrogenase (1993), Biochem. Mol. Biol. Int., 30, 525-535.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| p-hydroxymercuribenzoate | - |
Mus musculus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
4-hydroxy-2-nonenal | - |
Mus musculus | |
| 0.06 | - |
NAD+ | - |
Mus musculus | |
| 0.08 | - |
hexanal | - |
Mus musculus | |
| 0.11 | - |
benzaldehyde | - |
Mus musculus | |
| 0.12 | - |
trans-2-hexenal | - |
Mus musculus | |
| 1.4 | - |
NADP+ | - |
Mus musculus | |
| 15.63 | - |
acetaldehyde | - |
Mus musculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 59000 | - |
2 * 59000, SDS-PAGE | Mus musculus |
| 110000 | - |
gel filtration | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | dual role for the corneal enzyme in providing the eye with protection against UV-B light: by oxidizing aldehydes generated through light-induced lipid peroxidation and by direct absorption of UV-B light by the enzyme | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cornea | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 5.51 | - |
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-hydroxy-2-nonenal + NADP+ + H2O | - |
Mus musculus | 4-hydroxy-2-nonenoic acid + NADPH + H+ | - |
r | |
| acetaldehyde + NAD+ + H2O | - |
Mus musculus | acetate + NADH + H+ | - |
? | |
| benzaldehyde + NAD+ + H2O | - |
Mus musculus | benzoate + NADH + H+ | - |
? | |
| benzaldehyde + NADP+ | - |
Mus musculus | benzoate + NADPH | - |
? | |
| hexanal + NAD+ + H2O | - |
Mus musculus | hexanoate + NADH + H+ | - |
? | |
| malondialdehyde + NAD+ | - |
Mus musculus | ? + NADH | - |
? | |
| additional information | enzyme prefers aldehyde products of lipid peroxidation as substrates | Mus musculus | ? | - |
? | |
| additional information | dual role for the corneal enzyme in providing the eye with protection against UV-B light: by oxidizing aldehydes generated through light-induced lipid peroxidation and by direct absorption of UV-B light by the enzyme | Mus musculus | ? | - |
? | |
| trans-2-hexenal + NAD+ | - |
Mus musculus | trans-2-hexenoate + NADH | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 59000, SDS-PAGE | Mus musculus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 18.8 | - |
NAD+ | reaction with benzyladehyde | Mus musculus | |
| 20.9 | - |
benzaldehyde | - |
Mus musculus | |
| 26.1 | - |
4-hydroxy-2-nonenal | - |
Mus musculus | |
| 33.1 | - |
NADP+ | reaction with benzaldehyde | Mus musculus | |
| 33.5 | - |
acetaldehyde | - |
Mus musculus | |
| 34 | - |
hexanal | - |
Mus musculus | |
| 35.1 | - |
trans-2-hexenal | - |
Mus musculus | |
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