Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
2 * 55000, SDS-PAGE | Mus musculus |
55000 | - |
2 * 55000, SDS-PAGE | Homo sapiens |
55000 | - |
2 * 55000, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cis,cis-9,12-octadecadienal + NAD+ + H2O | Mus musculus | major substrate | cis,cis-9,12-octadecadienoic acid + NADH | - |
? | |
cis,cis-9,12-octadecadienal + NAD+ + H2O | Homo sapiens | major substrate | cis,cis-9,12-octadecadienoic acid + NADH | - |
? | |
cis,cis-9,12-octadecadienal + NAD+ + H2O | Rattus norvegicus | major substrate | cis,cis-9,12-octadecadienoic acid + NADH | - |
? | |
long-chain aldehyde + NAD+ + H2O | Mus musculus | - |
long-chain acid anion + NADH | - |
? | |
long-chain aldehyde + NAD+ + H2O | Homo sapiens | - |
long-chain carboxylate + NADH | - |
? | |
long-chain aldehyde + NAD+ + H2O | Rattus norvegicus | - |
long-chain carboxylate + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Strep-tag affinity chromatography and AMP-Sepharose column chromatography | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Mus musculus | - |
cerebellum | - |
Mus musculus | - |
cerebrum | - |
Mus musculus | - |
fibroblast | - |
Homo sapiens | - |
heart | low activity | Mus musculus | - |
kidney | - |
Mus musculus | - |
large intestine | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |
lung | - |
Mus musculus | - |
ovary | high activity | Mus musculus | - |
skeletal muscle | low activity | Mus musculus | - |
spleen | - |
Mus musculus | - |
stomach | - |
Mus musculus | - |
stomach | high activity | Mus musculus | - |
subcutaneous adipose tissue | - |
Mus musculus | - |
testis | high activity | Mus musculus | - |
visceral fat | high activity | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cis,cis-9,12-octadecadienal + NAD+ + H2O | major substrate | Mus musculus | cis,cis-9,12-octadecadienoic acid + NADH | - |
? | |
cis,cis-9,12-octadecadienal + NAD+ + H2O | major substrate | Homo sapiens | cis,cis-9,12-octadecadienoic acid + NADH | - |
? | |
cis,cis-9,12-octadecadienal + NAD+ + H2O | major substrate | Rattus norvegicus | cis,cis-9,12-octadecadienoic acid + NADH | - |
? | |
long-chain aldehyde + NAD+ + H2O | - |
Mus musculus | long-chain acid anion + NADH | - |
? | |
long-chain aldehyde + NAD+ + H2O | - |
Homo sapiens | long-chain carboxylate + NADH | - |
? | |
long-chain aldehyde + NAD+ + H2O | - |
Rattus norvegicus | long-chain carboxylate + NADH | - |
? | |
pyrenedecanal + NAD+ + H2O | - |
Mus musculus | pyrenedecanoic acid + NADH | - |
? | |
pyrenedecanal + NAD+ + H2O | - |
Homo sapiens | pyrenedecanoic acid + NADH | - |
? | |
pyrenedecanal + NAD+ + H2O | - |
Rattus norvegicus | pyrenedecanoic acid + NADH | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 55000, SDS-PAGE | Mus musculus |
homodimer | 2 * 55000, SDS-PAGE | Homo sapiens |
homodimer | 2 * 55000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
ALDH3A2 | - |
Mus musculus |
ALDH3A2 | - |
Homo sapiens |
ALDH3A2 | - |
Rattus norvegicus |
fatty aldehyde dehydrogenase | - |
Mus musculus |
fatty aldehyde dehydrogenase | - |
Homo sapiens |
fatty aldehyde dehydrogenase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mus musculus | |
NAD+ | - |
Homo sapiens | |
NAD+ | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | deficiency in fatty aldehyde dehydrogenase causes the Sjogren Larsson Syndrome, a rare inherited disorder characterized by ichthyosis, spasticity, and mental retardation | Homo sapiens |