Application | Comment | Organism |
---|---|---|
medicine | in humans a natural S352L mutation gives rise to type II hyperprolinemia, mental retardation | Thermus thermophilus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamate 5-semialdehyde + phosphate + NAD+ | Thermus thermophilus | - |
L-glutamyl 5-phosphate + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Thermus thermophilus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamate 5-semialdehyde + phosphate + NAD+ | - |
Thermus thermophilus | L-glutamyl 5-phosphate + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
hexamer | composed by dimers | Thermus thermophilus |
Synonyms | Comment | Organism |
---|---|---|
ALDH4 | - |
Thermus thermophilus |
gamma glutamyl semialdehyde dehydrogenase | - |
Thermus thermophilus |
GGSALDH | - |
Thermus thermophilus |
pyrroline 5-carboxylate dehydrogenase | - |
Thermus thermophilus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | the work based on a computer simulation using a PDB data set of Thermus thermophilus GGSALDH, pdb2BJA, in this structure the enzyme is co-crystallized with NADH | Thermus thermophilus |