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Literature summary for 1.2.1.41 extracted from

  • Saum, S.H.; Mueller, V.
    Salinity-dependent switching of osmolyte strategies in a moderately halophilic bacterium: glutamate induces proline biosynthesis in Halobacillus halophilus (2007), J. Bacteriol., 189, 6968-6975.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information cellular mRNA levels are increased up to 90fold in the presence of glutamate. A minimal concentration of 0.2 M glutamate already stimulates proA gene expression Halobacillus halophilus

Application

Application Comment Organism
additional information the genes proH encoding pyrroline-5-carboxylate reductase, proJ encoding glutamate-5-kinase, and proA encoding glutamate-5-semialdehyde dehydrogenase form a transcriptional unit. This pro operon is involved in salinity-induced proline biosynthesis Halobacillus halophilus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information expression of the proA gene is salinity-dependent and reaches a maximum at 2.5 M NaCl Halobacillus halophilus

Organism

Organism UniProt Comment Textmining
Halobacillus halophilus A7Y114 strain DSMZ 2266T
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate 5-semialdehyde + phosphate + NADP+
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Halobacillus halophilus L-5-glutamyl phosphate + NADPH + H+
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