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Literature summary for 1.2.1.4 extracted from

  • Short, D.M.; Lyon, R.; Watson, D.G.; Barski, O.A.; McGarvie, G.; Ellis, E.M.
    Metabolism of trans, trans-muconaldehyde, acytotoxic metabolite of benzene, in mouse liver by alcohol dehydrogenase Adh1 and aldehyde reductase AKR1A4 (2006), Toxicol. Appl. Pharmacol., 210, 163-170.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
into the pET28a vector for expression in Escherichia coli Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.015
-
muconaldehyde
-
Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
predicted Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an aldehyde + NADP+ + H2O Mus musculus
-
an acid + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q540D7
-
-

Purification (Commentary)

Purification (Comment) Organism
using a Q-sepharose anion exchange column for enzyme preparation of mouse liver, using nickel agarose affinity chromatography for purification of recombinant protein Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
an aldehyde + NADP+ + H2O
-
Mus musculus an acid + NADPH + H+
-
?
trans,trans-muconaldehyde + NADP+ + H2O
-
Mus musculus trans,trans-muconic acid + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
AKR1A4
-
Mus musculus
aldehyde dehydrogenase (NADP+)
-
Mus musculus
aldehyde reductase
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
activity assay Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
activity assay Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mus musculus

pI Value

Organism Comment pI Value Maximum pI Value
Mus musculus
-
-
7.2