Application | Comment | Organism |
---|---|---|
medicine | activity of any one isoform is not rate limiting in the visual response | Mus musculus |
additional information | similar localization of Rdh12 and RDH12 proteins in mouse and human photoreceptors, respectively, which may indicate an analogous physiological role of the enzymes in both species | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
into the pKO-V901 plasmid | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | Rdh12-/- mice are viable, develop normally, and can not be distinguished from heterozygous or wild-type littermates by mere observation. Rdh12 knockout mice exhibit grossly normal retinal histology at 10 months of age. Lipid peroxidation products and other measures of oxidative stress are not elevated in Rdh12-/- animals. Rdh12-/- and wild-type mice show approximately equivalent expression of the visual cycle genes Rdh5, Rpe65, Lrat, Cralbp, Crbp, Irbp, Rho, and Abcr. There is also no change in the expression of other Rdh isoforms expressed in photoreceptors, including Rdh8 (prRdh), Rdh11, Rdh13, Rdh14, and retSDR1 | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
cross between 129/Sv and C57BL/6 mouse strains | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
retina | photoreceptor inner segments and the outer nuclear layer | Mus musculus | - |
retina | photoreceptor inner segments and the outer nuclear layer | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
RDH12 | - |
Mus musculus |