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Literature summary for 1.2.1.31 extracted from
- Posttranslational activation, site-directed mutation and phylogenetic analyses of the lysine biosynthesis enzymes alpha-aminoadipate reductase Lys1p (AAR) and the phosphopantetheinyl transferase Lys7p (PPTase) from Schizosaccharomyces pombe (2004), Yeast, 21, 1279-1288.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Schizosaccharomyces pombe |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli as an active enzyme. Exhibits significant alpha-aminoadipate reductase activity without the addition of CoA and Lys7p PPTase from Schizosaccharomyces pombe | Schizosaccharomyces pombe |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C125I | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
| D126E | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
| D94E | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
| E173D | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
| F93W | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
| F95W | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
| G124A | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
| G79A | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
| G910A | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
| K172R | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
| K177R | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
| N96D | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
| P81A | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
| R80K | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
| S913A | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
| S913T | mutant enzyme shows no alpha-aminoadipate reductase activity | Schizosaccharomyces pombe |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-2-aminoadipate + NADPH + H+ | Schizosaccharomyces pombe | - |
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schizosaccharomyces pombe | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Schizosaccharomyces pombe |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-2-aminoadipate + NADPH + H+ | - |
Schizosaccharomyces pombe | L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? | |
| L-2-aminoadipate + NADPH + H+ | in presence of ATP | Schizosaccharomyces pombe | L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AAR | - |
Schizosaccharomyces pombe |
| alpha-aminoadipate reductase Lys1p | - |
Schizosaccharomyces pombe |
| Lys1p | - |
Schizosaccharomyces pombe |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Schizosaccharomyces pombe | |
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