Inhibitors | Comment | Organism | Structure |
---|---|---|---|
delta-hydroxylysine | competitive with respect to alpha-aminoadipate, non-competitive with respect to both ATP and NADPH | Blastobotrys adeninivorans | |
L-lysine | competitive with respect to alpha-aminoadipate, non-competitive with respect to both ATP and NADPH | Blastobotrys adeninivorans | |
S-(beta-aminoethyl)-L-cysteine | competitive with respect to alpha-aminoadipate, non-competitive with respect to both ATP and NADPH | Blastobotrys adeninivorans |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.23 | - |
NADPH | - |
Blastobotrys adeninivorans | |
0.77 | - |
MgCl2 | - |
Blastobotrys adeninivorans | |
0.78 | - |
alpha-aminoadipate | - |
Blastobotrys adeninivorans | |
1 | - |
ATP | - |
Blastobotrys adeninivorans |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required for activity | Blastobotrys adeninivorans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alpha-aminoadipate + NAD(P)H | Blastobotrys adeninivorans | in presence of ATP and Mg2+ | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
L-alpha-aminoadipate + NAD(P)H | Blastobotrys adeninivorans | sixth step of lysine biosynthesis | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Blastobotrys adeninivorans | - |
- |
- |
Purification (Comment) | Organism |
---|---|
using DEAE-cellulose column chromatography | Blastobotrys adeninivorans |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Blastobotrys adeninivorans |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-aminoadipic semialdehyde + NAD+ + H2O | - |
Blastobotrys adeninivorans | alpha-aminoadipic acid + NADH + H+ | - |
? | |
L-2-aminoadipate + NADPH | in presence of ATP + Mg2+ | Blastobotrys adeninivorans | L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? | |
L-alpha-aminoadipate + NAD(P)H | in presence of ATP and Mg2+ | Blastobotrys adeninivorans | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
L-alpha-aminoadipate + NAD(P)H | sixth step of lysine biosynthesis | Blastobotrys adeninivorans | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | 8.7 | - |
Blastobotrys adeninivorans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Blastobotrys adeninivorans |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | - |
S-(beta-aminoethyl)-L-cysteine | - |
Blastobotrys adeninivorans | |
0.09 | - |
L-lysine | - |
Blastobotrys adeninivorans | |
1.65 | - |
delta-hydroxylysine | - |
Blastobotrys adeninivorans |