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Literature summary for 1.2.1.3 extracted from
- Characterization of an aldehyde dehydrogenase from Euglena gracilis (2006), J. Eukaryot. Microbiol., 53, 36-42.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Disulfiram | - |
Euglena gracilis |  |
| p-hydroxyacetophenone | - |
Euglena gracilis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0053 | - |
propanal | 100 mM Na2HPO4, pH 7.4, 100 mM NaCl, 1 mM NAD+, 25°C | Euglena gracilis | |
| 0.01 | - |
acetaldehyde | 100 mM Na2HPO4, pH 7.4, 100 mM NaCl, 1 mM NAD+, 25°C | Euglena gracilis | |
| 0.047 | - |
NAD+ | 100 mM Na2HPO4, pH 7.4, 100 mM NaCl, 1 mM NAD+, 25°C | Euglena gracilis | |
| 0.15 | - |
benzaldehyde | 100 mM Na2HPO4, pH 7.4, 100 mM NaCl, 1 mM NAD+, 25°C | Euglena gracilis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Euglena gracilis | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Euglena gracilis | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40000 | - |
SDS-PAGE | Euglena gracilis |
| 160000 | - |
gel-filtration | Euglena gracilis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Euglena gracilis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| enzyme purified from the mitochondrial fraction by p-hydroxyacetophenone affinity chromatography | Euglena gracilis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetaldehyde + NAD+ + H2O | - |
Euglena gracilis | acetate + NADH + H+ | - |
? | |
| benzaldehyde + NAD+ + H2O | - |
Euglena gracilis | benzoate + NADH + H+ | - |
? | |
| propanal + NAD+ + H2O | - |
Euglena gracilis | propionate + NADH | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 40000, gel-filtration | Euglena gracilis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aldehyde dehydrogenase | - |
Euglena gracilis |
| ALDH | - |
Euglena gracilis |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | 35 | full activity after 5 min | Euglena gracilis |
| 40 | - |
50% activity after 5 min | Euglena gracilis |
| 50 | - |
no activity after 5 min | Euglena gracilis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9.5 | - |
- |
Euglena gracilis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Euglena gracilis | |
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Release 2023.1 (January 2023)
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