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Literature summary for 1.2.1.3 extracted from

  • Vallari, R.C.; Pietruszko, R.
    Kinetic mechanism of the human cytoplasmic aldehyde dehydrogenase E1 (1981), Arch. Biochem. Biophys., 212, 9-19.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
adenosine 5'-monophosphate competitive with NAD+ and noncompetitive with acetaldehyde Homo sapiens
Chloral hydrate competitive with respect to acetaldehyde Homo sapiens
Disulfiram strong inhibition of isoenzyme 1, no inhibition of isoenzyme 2 Homo sapiens
NADH competitive with NAD+ at high and low concentrations of acetaldehyde, product inhibitor Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002 0.003 acetaldehyde isoenzyme 2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
enzyme I and II Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
an aldehyde + NAD+ + H2O = a carboxylate + NADH + H+ mechanism proceeds mainly through an enzyme*NAD+ binary complex, but at high concentrations of acetaldehyde a small degree of randomness is observed, the rate-limiting step of the dehydrogenase reaction occurs after ternary complex interconversion Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens