Protein Variants | Comment | Organism |
---|---|---|
A237S | the mutant shows 65% activity compared to the wild type enzyme | Homo sapiens |
C223Y | the mutant shows 5% activity compared to the wild type enzyme | Homo sapiens |
C93F | the mutant shows 3% activity compared to the wild type enzyme | Homo sapiens |
G176R | the mutant shows less than 1% activity compared to the wild type enzyme | Homo sapiens |
G268E | the mutant shows less than 1% activity compared to the wild type enzyme | Homo sapiens |
G409D | the mutant shows less than 1% activity compared to the wild type enzyme | Homo sapiens |
G46R | the mutant shows 87% activity compared to the wild type enzyme | Homo sapiens |
G533R | the mutant shows less than 1% activity compared to the wild type enzyme | Homo sapiens |
H180Y | the mutant shows 83% activity compared to the wild type enzyme | Homo sapiens |
N255S | the mutant shows 17% activity compared to the wild type enzyme | Homo sapiens |
N335K | the mutant shows 1% activity compared to the wild type enzyme | Homo sapiens |
P182L | the mutant shows 48% activity compared to the wild type enzyme | Homo sapiens |
P382L | the mutant shows 2% activity compared to the wild type enzyme | Homo sapiens |
T233M | the mutant shows 4% activity compared to the wild type enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinate semialdehyde + NAD+ + H2O | Homo sapiens | - |
succinate + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P51649 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinate semialdehyde + NAD+ + H2O | - |
Homo sapiens | succinate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SSADH | - |
Homo sapiens |
succinic semialdehyde dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | SSADH plays an essential role in the metabolism of the inhibitory neurotransmitter c-aminobutyric acid | Homo sapiens |