Literature summary for 1.2.1.24 extracted from

Sauer, S.W.; Koelker, S.; Hoffmann, G.F.; Ten Brink, H.J.; Jakobs, C.; Gibson, K.M.; Okun, J.G.
Enzymatic and metabolic evidence for a region specific mitochondrial dysfunction in brains of murine succinic semialdehyde dehydrogenase deficiency (Aldh5a1-/- mice) (2007), Neurochem. Int., 50, 653-659.

Search for more literature for 1.2.1.24

Application

Application	Comment	Organism
medicine	SSADH (Aldh5a1) deficiency is a rare autosomal recessive disease. Hippocampal and cortical dysfunction in Aldh5a1-/- brain, but no evidence that accumulating key metabolites of SSADH deficiency directly induce impairment of energy metabolism	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	Aldh5a1-/- mice show abnormalities of respiratory chain function. Hippocampus and cortex are primary targets for neurodegeneration	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Mus musculus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8BWF0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain cortex	-	Mus musculus	-
hippocampus	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
succinate semialdehyde + NAD+ + H2O	-	Mus musculus	succinate + NADH + H+	-	?

Synonyms

Synonyms	Comment	Organism
ALDH5A1	-	Mus musculus
SSADH	-	Mus musculus
succinic semialdehyde dehydrogenase	-	Mus musculus

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Release 2023.1 (January 2023)