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Literature summary for 1.2.1.24 extracted from
- Succinic semialdehyde dehydrogenase: purification and properties of the enzyme from monkey brain (1961), Biochim. Biophys. Acta, 52, 29-35.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| sodium lauryl sulfate | low concentrations activate to a small extent | Platyrrhini |  |
General Stability
| General Stability | Organism |
|---|---|
| denaturation by sodium lauryl sulfate | Platyrrhini |
| NAD+ and mercaptoethanol effectively protect from auto-oxidation. NAD+ does not prevent auto-oxidation in presence of urea | Platyrrhini |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxybenzaldehyde | - |
Platyrrhini | |
| arsenite | - |
Platyrrhini | |
| m-hydroxybenzaldehyde | - |
Platyrrhini | |
| NEM | - |
Platyrrhini | |
| p-chloromercuriphenyl sulfonate | - |
Platyrrhini | |
| succinate semialdehyde | substrate inhibition above 0.02 mM | Platyrrhini | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Platyrrhini | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Platyrrhini |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Platyrrhini | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate semialdehyde + NAD+ + H2O | - |
Platyrrhini | succinate + NADH | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
pH 7.4, 8 min, complete inactivation. Mercaptoethanol stabilizes for 20 min or longer | Platyrrhini |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.7 | 9.1 | - |
Platyrrhini |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Platyrrhini |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 3-acetylpyridine adenine dinucleotide | reduced at nearly the same rate as NAD+ | Platyrrhini | |
| deamino-NAD+ | reduced at nearly the same rate as NAD+ | Platyrrhini | |
| NAD+ | - |
Platyrrhini | |
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Release 2023.1 (January 2023)
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