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Literature summary for 1.2.1.22 extracted from

  • Greig, N.; Wyllie, S.; Patterson, S.; Fairlamb, A.H.
    A comparative study of methylglyoxal metabolism in trypanosomatids (2009), FEBS J., 276, 376-386.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.22

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-lactaldehyde + NAD+ + H2O Trypanosoma brucei
-
 (S)-lactate + NADH + 2 H+
-
 ?
(S)-lactaldehyde + NAD+ + H2O Trypanosoma cruzi
-
 (S)-lactate + NADH + 2 H+
-
 ?
(S)-lactaldehyde + NAD+ + H2O Leishmania major
-
 (S)-lactate + NADH + 2 H+
-
 ?
(S)-lactaldehyde + NAD+ + H2O Leishmania major Friedlin
-
 (S)-lactate + NADH + 2 H+
-
 ?
additional information Trypanosoma brucei the enzyme shows NAD+-dependent l-lactaldehyde dehydrogenase activity in the methylglyoxyl metabolism, metabolizing methylglyoxal via methylglyoxal reductase and lactaldehyde dehydrogenase to L-lactate, overview ?
-
 ?
additional information Trypanosoma cruzi the enzyme shows NAD+-dependent l-lactaldehyde dehydrogenase activity in the methylglyoxyl metabolism, metabolizing methylglyoxal via methylglyoxal reductase and lactaldehyde dehydrogenase to L-lactate, overview ?
-
 ?
additional information Leishmania major the enzyme shows NAD+-dependent l-lactaldehyde dehydrogenase activity in the methylglyoxyl metabolism, metabolizing methylglyoxal via methylglyoxal reductase and lactaldehyde dehydrogenase to L-lactate, overview ?
-
 ?
additional information Leishmania major Friedlin the enzyme shows NAD+-dependent l-lactaldehyde dehydrogenase activity in the methylglyoxyl metabolism, metabolizing methylglyoxal via methylglyoxal reductase and lactaldehyde dehydrogenase to L-lactate, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania major
-
-
-
Trypanosoma brucei
-
-
-
Trypanosoma cruzi
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information no activity in the bloodstream stage of the parasite Trypanosoma brucei
-
procyclic form
-
 Trypanosoma brucei
-
trypanosomoid form
-
 Trypanosoma brucei
-
trypanosomoid form
-
 Trypanosoma cruzi
-
trypanosomoid form
-
 Leishmania major
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00048
-
 whole cell lysate Trypanosoma cruzi
0.00051
-
 whole cell lysate Leishmania major
0.00051
-
 whole cell lysate, procyclics Trypanosoma brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactaldehyde + NAD+ + H2O
-
 Trypanosoma brucei (S)-lactate + NADH + 2 H+
-
 ?
(S)-lactaldehyde + NAD+ + H2O
-
 Trypanosoma cruzi (S)-lactate + NADH + 2 H+
-
 ?
(S)-lactaldehyde + NAD+ + H2O
-
 Leishmania major (S)-lactate + NADH + 2 H+
-
 ?
(S)-lactaldehyde + NAD+ + H2O
-
 Leishmania major Friedlin (S)-lactate + NADH + 2 H+
-
 ?
additional information the enzyme shows NAD+-dependent l-lactaldehyde dehydrogenase activity in the methylglyoxyl metabolism, metabolizing methylglyoxal via methylglyoxal reductase and lactaldehyde dehydrogenase to L-lactate, overview Trypanosoma brucei ?
-
 ?
additional information the enzyme shows NAD+-dependent l-lactaldehyde dehydrogenase activity in the methylglyoxyl metabolism, metabolizing methylglyoxal via methylglyoxal reductase and lactaldehyde dehydrogenase to L-lactate, overview Trypanosoma cruzi ?
-
 ?
additional information the enzyme shows NAD+-dependent l-lactaldehyde dehydrogenase activity in the methylglyoxyl metabolism, metabolizing methylglyoxal via methylglyoxal reductase and lactaldehyde dehydrogenase to L-lactate, overview Leishmania major ?
-
 ?
additional information the enzyme shows NAD+-dependent l-lactaldehyde dehydrogenase activity in the methylglyoxyl metabolism, metabolizing methylglyoxal via methylglyoxal reductase and lactaldehyde dehydrogenase to L-lactate, overview Leishmania major Friedlin ?
-
 ?

Synonyms

Synonyms Comment Organism
L-lactaldehyde dehydrogenase
-
 Trypanosoma brucei
L-lactaldehyde dehydrogenase
-
 Trypanosoma cruzi
L-lactaldehyde dehydrogenase
-
 Leishmania major
LADH
-
 Trypanosoma brucei
LADH
-
 Trypanosoma cruzi
LADH
-
 Leishmania major

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Trypanosoma brucei
NAD+ dependent on Trypanosoma cruzi
NAD+ dependent on Leishmania major