Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.1.13 extracted from

  • Lee, W.H.; Kim, M.D.; Jin, Y.S.; Seo, J.H.
    Engineering of NADPH regenerators in Escherichia coli for enhanced biotransformation (2013), Appl. Microbiol. Biotechnol., 97, 2761-2772.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Clostridium acetobutylicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glyceraldehyde 3-phosphate + phosphate + NADP+ Clostridium acetobutylicum
-
3-phospho-D-glyceroyl phosphate + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Clostridium acetobutylicum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glyceraldehyde 3-phosphate + phosphate + NADP+
-
Clostridium acetobutylicum 3-phospho-D-glyceroyl phosphate + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
GAPC
-
Clostridium acetobutylicum
NADP-dependent GAPDH
-
Clostridium acetobutylicum
NADP-dependent glyceradehdye-3-phosphate dehydrogenase
-
Clostridium acetobutylicum

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Clostridium acetobutylicum

General Information

General Information Comment Organism
physiological function with the aid of the gapC gene, NADPH-dependent production of lycopene and epsilon-caprolactone is enhanced by 150 and 95%, respectively. Especially, overexpression of gapC significantly reduces the carbon flux to the pentose phosphate pathway (80% decrease) Clostridium acetobutylicum