Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.1.12 extracted from

  • Vazquez-Zamorano, Z.E.; Gonzalez-Lopez, M.A.; Romero-Espejel, M.E.; Azuara-Liceaga, E.I.; Lopez-Casamichana, M.; Olivares-Trejo, J.d.e. .J.
    Streptococcus pneumoniae secretes a glyceraldehyde-3-phosphate dehydrogenase, which binds haemoglobin and haem (2014), Biometals, 27, 683-693 .
    View publication on PubMed
Search for more literature for 1.2.1.12

Cloned(Commentary)

Cloned (Comment) Organism
gene gapA, sequence comparisons Streptococcus pneumoniae

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Streptococcus pneumoniae
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38000
-
 native PAGE Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glyceraldehyde 3-phosphate + phosphate + NAD+ Streptococcus pneumoniae
-
 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 ?
additional information Streptococcus pneumoniae the enzyme binds hemoglobin and heme, it is a heme-binding protein ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae Q8CWN6
-
-

Purification (Commentary)

Purification (Comment) Organism
purification of the secreted protein from the secretome of iron-starved cells by heme affinity chromatography with enzyme elution through a 6 M guanidine hydrochloride solution Streptococcus pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
 Streptococcus pneumoniae 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 ?
additional information the enzyme binds hemoglobin and heme, it is a heme-binding protein Streptococcus pneumoniae ?
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 38000, SDS-PAGE, 1 * 38760, mass spectrometry Streptococcus pneumoniae
More enzyme modeling Streptococcus pneumoniae

Synonyms

Synonyms Comment Organism
GapA
-
 Streptococcus pneumoniae
GAPDH
-
 Streptococcus pneumoniae
glyceraldehyde-3-phosphate dehydrogenase
-
 Streptococcus pneumoniae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Streptococcus pneumoniae

pI Value

Organism Comment pI Value Maximum pI Value
Streptococcus pneumoniae isoelectric focusing
-
 5.37

General Information

General Information Comment Organism
physiological function the enzyme of the human pathogen binds hemoglobin and heme, it is a heme-binding protein and might be playing a dynamic role in the success of the invasive and infective processes of this pathogen Streptococcus pneumoniae