Literature summary for 1.2.1.12 extracted from

Jenkins, J.L.; Tanner, J.J.
High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase (2006), Acta Crystallogr. Sect. D, D62, 290-301.

Search for more literature for 1.2.1.12

Application

Application	Comment	Organism
medicine	target for the design of antitrypanosomatid and anti-apoptosis drugs	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
subcloned into a pET14b vector for expression in Escherichia coli BL21DE3 cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
a high-resolution structure of 1.75 A is reported	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
CGP-3466	deprenyl-related compound that inhibits the pro-apoptotic activity of GAPDH	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-glyceraldehyde 3-phosphate + phosphate + NAD+	Homo sapiens	-	3-phospho-D-glyceroyl phosphate + NADH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
using Ni-NTA resin and a HiTrap Blue column, the His tag is removed	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
placenta	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glyceraldehyde 3-phosphate + phosphate + NAD+	-	Homo sapiens	3-phospho-D-glyceroyl phosphate + NADH + H+	-	?

Synonyms

Synonyms	Comment	Organism
D-glyceraldehyde-3-phosphate dehydrogenase	-	Homo sapiens
GAPDH	-	Homo sapiens
HsGAPDH	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADH	-	Homo sapiens

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Release 2023.1 (January 2023)