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Literature summary for 1.2.1.12 extracted from
- Substituting selenocysteine for active site cysteine 149 of phosphorylating glyceraldehyde 3-phosphate dehydrogenase reveals a peroxidase activity (1998), FEBS Lett., 439, 241-245.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C149selenocysteine | mutant enzyme has selenoperoxidase activity | Geobacillus stearothermophilus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Geobacillus stearothermophilus | - |
wild-type enzyme and mutant C149selenocysteine | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| mutant enzyme C149selenocysteine | Geobacillus stearothermophilus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glyceraldehyde 3-phosphate + phosphate + NAD+ | - |
Geobacillus stearothermophilus | 3-phospho-D-glyceroyl phosphate + NADH | - |
? |  |
| additional information | mutant enzyme C149selenocysteine shows selenoperoxidase activity with tert-butyl hydroperoxide and 3-carboxy 4-nitrobenzenethiol. Wild-type enzyme has no peroxidase activity | Geobacillus stearothermophilus | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Geobacillus stearothermophilus | |
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