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Literature summary for 1.2.1.11 extracted from

  • Vyas, R.; Tewari, R.; Weiss, M.S.; Karthikeyan, S.
    Structures of ternary complexes of aspartate-semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis H37Rv (2012), Acta Crystallogr. Sect. D, 68, 671-679.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli M15 cells Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with S-methyl-l-cysteine sulfoxide and sulfate, sitting drop vapor diffusion method, using 1.6 M ammonium sulfate and 100 mM citric acid pH 5.0 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-4-aspartyl phosphate + NADPH + H+ Mycobacterium tuberculosis
-
L-aspartate 4-semialdehyde + phosphate + NADP+
-
?
L-4-aspartyl phosphate + NADPH + H+ Mycobacterium tuberculosis H37Rv
-
L-aspartate 4-semialdehyde + phosphate + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WNX5
-
-
Mycobacterium tuberculosis H37Rv P9WNX5
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography and gel filtration Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-4-aspartyl phosphate + NADPH + H+
-
Mycobacterium tuberculosis L-aspartate 4-semialdehyde + phosphate + NADP+
-
?
L-4-aspartyl phosphate + NADPH + H+
-
Mycobacterium tuberculosis H37Rv L-aspartate 4-semialdehyde + phosphate + NADP+
-
?

Synonyms

Synonyms Comment Organism
ASADH
-
Mycobacterium tuberculosis
Asd
-
Mycobacterium tuberculosis
Rv3708c
-
Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mycobacterium tuberculosis

General Information

General Information Comment Organism
metabolism the enzyme lies at the first branch point in the biosynthetic pathway of important amino acids including lysine and methionine and the cell-wall component diaminopimelate Mycobacterium tuberculosis