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Literature summary for 1.2.1.10 extracted from

  • Sanchez, L.B.
    Aldehyde dehydrogenase (CoA-acetylating) and the mechanism of ethanol formation in the amitochondriate protist, Giardia lamblia (1998), Arch. Biochem. Biophys., 354, 57-64.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ 5 mM causes 51% inhibition Giardia intestinalis
Disulfiram 0.01 mM causes 70% inhibition Giardia intestinalis
iodoacetamide 1 mM causes 88-96% inhibition Giardia intestinalis
Mg2+ 5 mM causes 51% inhibition Giardia intestinalis
Mn2+ 5 mM causes 84% inhibition Giardia intestinalis
p-chloromercuribenzoate 0.01 mM causes 88-96% inhibition Giardia intestinalis
Valproate 50 mM causes 20-46% inhibition Giardia intestinalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.018
-
acetyl-CoA
-
Giardia intestinalis
0.022
-
NADH
-
Giardia intestinalis
0.076
-
CoA
-
Giardia intestinalis
0.362
-
acetaldehyde
-
Giardia intestinalis
0.603
-
propanal
-
Giardia intestinalis

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Giardia intestinalis 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
95000
-
x * 95000, SDS-PAGE, amino acid sequence Giardia intestinalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetaldehyde + CoA + NAD+ Giardia intestinalis
-
acetyl-CoA + NADH
-
r
acetaldehyde + CoA + NAD+ Giardia intestinalis WB / CC 30957
-
acetyl-CoA + NADH
-
r
propanal + CoA + NAD+ Giardia intestinalis is used 63% as efficiently as acetaldehyde propionyl-CoA + NADH
-
r
propanal + CoA + NAD+ Giardia intestinalis WB / CC 30957 is used 63% as efficiently as acetaldehyde propionyl-CoA + NADH
-
r

Organism

Organism UniProt Comment Textmining
Giardia intestinalis
-
srain WB
-
Giardia intestinalis WB / CC 30957
-
srain WB
-

Purification (Commentary)

Purification (Comment) Organism
-
Giardia intestinalis

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
8.75
-
bifunctional fusion protein of aldehyde and alcohol dehydrogenase Giardia intestinalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + CoA + NAD+
-
Giardia intestinalis acetyl-CoA + NADH
-
r
acetaldehyde + CoA + NAD+ enzyme carries aldehyde and alcohol dehydrogenase activity Giardia intestinalis acetyl-CoA + NADH
-
r
acetaldehyde + CoA + NAD+
-
Giardia intestinalis WB / CC 30957 acetyl-CoA + NADH
-
r
acetaldehyde + CoA + NAD+ enzyme carries aldehyde and alcohol dehydrogenase activity Giardia intestinalis WB / CC 30957 acetyl-CoA + NADH
-
r
formaldehyde + CoA + NAD+
-
Giardia intestinalis formyl-CoA + NADH
-
ir
isobutyraldehyde + CoA + NAD+
-
Giardia intestinalis isobutyryl-CoA + NADH
-
r
isobutyraldehyde + CoA + NAD+
-
Giardia intestinalis WB / CC 30957 isobutyryl-CoA + NADH
-
r
n-butyraldehyde + CoA + NAD+
-
Giardia intestinalis n-butyryl-CoA + NADH
-
?
n-butyraldehyde + CoA + NAD+
-
Giardia intestinalis WB / CC 30957 n-butyryl-CoA + NADH
-
?
propanal + CoA + NAD+ is used 63% as efficiently as acetaldehyde Giardia intestinalis propionyl-CoA + NADH
-
r
propanal + CoA + NAD+ is used 63% as efficiently as acetaldehyde Giardia intestinalis WB / CC 30957 propionyl-CoA + NADH
-
r

Subunits

Subunits Comment Organism
? x * 95000, SDS-PAGE, amino acid sequence Giardia intestinalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
NAD+ reduction Giardia intestinalis

Cofactor

Cofactor Comment Organism Structure
CoA
-
Giardia intestinalis
NAD+ NAD+-specific Giardia intestinalis
NAD+ no reaction with NADP+ Giardia intestinalis