Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 5 mM causes 51% inhibition | Giardia intestinalis | |
Disulfiram | 0.01 mM causes 70% inhibition | Giardia intestinalis | |
iodoacetamide | 1 mM causes 88-96% inhibition | Giardia intestinalis | |
Mg2+ | 5 mM causes 51% inhibition | Giardia intestinalis | |
Mn2+ | 5 mM causes 84% inhibition | Giardia intestinalis | |
p-chloromercuribenzoate | 0.01 mM causes 88-96% inhibition | Giardia intestinalis | |
Valproate | 50 mM causes 20-46% inhibition | Giardia intestinalis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.018 | - |
acetyl-CoA | - |
Giardia intestinalis | |
0.022 | - |
NADH | - |
Giardia intestinalis | |
0.076 | - |
CoA | - |
Giardia intestinalis | |
0.362 | - |
acetaldehyde | - |
Giardia intestinalis | |
0.603 | - |
propanal | - |
Giardia intestinalis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Giardia intestinalis | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
95000 | - |
x * 95000, SDS-PAGE, amino acid sequence | Giardia intestinalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetaldehyde + CoA + NAD+ | Giardia intestinalis | - |
acetyl-CoA + NADH | - |
r | |
acetaldehyde + CoA + NAD+ | Giardia intestinalis WB / CC 30957 | - |
acetyl-CoA + NADH | - |
r | |
propanal + CoA + NAD+ | Giardia intestinalis | is used 63% as efficiently as acetaldehyde | propionyl-CoA + NADH | - |
r | |
propanal + CoA + NAD+ | Giardia intestinalis WB / CC 30957 | is used 63% as efficiently as acetaldehyde | propionyl-CoA + NADH | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Giardia intestinalis | - |
srain WB | - |
Giardia intestinalis WB / CC 30957 | - |
srain WB | - |
Purification (Comment) | Organism |
---|---|
- |
Giardia intestinalis |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
8.75 | - |
bifunctional fusion protein of aldehyde and alcohol dehydrogenase | Giardia intestinalis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetaldehyde + CoA + NAD+ | - |
Giardia intestinalis | acetyl-CoA + NADH | - |
r | |
acetaldehyde + CoA + NAD+ | enzyme carries aldehyde and alcohol dehydrogenase activity | Giardia intestinalis | acetyl-CoA + NADH | - |
r | |
acetaldehyde + CoA + NAD+ | - |
Giardia intestinalis WB / CC 30957 | acetyl-CoA + NADH | - |
r | |
acetaldehyde + CoA + NAD+ | enzyme carries aldehyde and alcohol dehydrogenase activity | Giardia intestinalis WB / CC 30957 | acetyl-CoA + NADH | - |
r | |
formaldehyde + CoA + NAD+ | - |
Giardia intestinalis | formyl-CoA + NADH | - |
ir | |
isobutyraldehyde + CoA + NAD+ | - |
Giardia intestinalis | isobutyryl-CoA + NADH | - |
r | |
isobutyraldehyde + CoA + NAD+ | - |
Giardia intestinalis WB / CC 30957 | isobutyryl-CoA + NADH | - |
r | |
n-butyraldehyde + CoA + NAD+ | - |
Giardia intestinalis | n-butyryl-CoA + NADH | - |
? | |
n-butyraldehyde + CoA + NAD+ | - |
Giardia intestinalis WB / CC 30957 | n-butyryl-CoA + NADH | - |
? | |
propanal + CoA + NAD+ | is used 63% as efficiently as acetaldehyde | Giardia intestinalis | propionyl-CoA + NADH | - |
r | |
propanal + CoA + NAD+ | is used 63% as efficiently as acetaldehyde | Giardia intestinalis WB / CC 30957 | propionyl-CoA + NADH | - |
r |
Subunits | Comment | Organism |
---|---|---|
? | x * 95000, SDS-PAGE, amino acid sequence | Giardia intestinalis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
NAD+ reduction | Giardia intestinalis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
CoA | - |
Giardia intestinalis | |
NAD+ | NAD+-specific | Giardia intestinalis | |
NAD+ | no reaction with NADP+ | Giardia intestinalis |