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Literature summary for 1.18.1.6 extracted from

  • Imamichi, Y.; Mizutani, T.; Ju, Y.; Matsumura, T.; Kawabe, S.; Kanno, M.; Yazawa, T.; Miyamoto, K.
    Transcriptional regulation of human ferredoxin reductase through an intronic enhancer in steroidogenic cells (2014), Biochim. Biophys. Acta, 1839, 33-42.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
KGN cell
-
Homo sapiens
-
NCI-H295R cell
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Homo sapiens
-

Synonyms

Synonyms Comment Organism
FDXR
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens a SF-1 binding region is located within intron 2 of the human FDXR gene. FDXR transcription is activated through the SF-1 binding site within intron 2. Endogenous SF-1 knockdown in human adrenocortical H295R and KGN cells decreased FDXR expression. In H295R cells, strong binding of two histone markers of active enhancers, histones H3K27ac and H3K4me2, is detected near the SF-1 binding site within intron 2. The binding of these histone markers is decreased concurrent with SF-1 knockdown in H295R cells additional information