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Literature summary for 1.18.1.6 extracted from

  • Cenas, N.; Marcinkeviciene, J.; Kulys, J.; Usanov, S.
    A negative cooperativity between NADPH and adrenodoxin on binding to NADPH:adrenodoxin reductase (1990), FEBS Lett., 259, 338-340.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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Bos taurus 5739
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Organism

Organism UniProt Comment Textmining
Bos taurus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
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Bos taurus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information adrenodoxin stimulates the oxidation of NADPH by 1,4-benzoquinone, catalyzed by NADPH:adrenodoxin reductase. It prevents the enzyme inhibition by NADPH and forms an additional pathway of benzoquinone reduction presumably via reduced adrenodoxin. Adrenodoxin decreases the affinity of the enzyme for NADPH by a limiting factor of 3 and NADP+ decreases the enzyme affinity for adrenodoxin Bos taurus ?
-
?
reduced adrenodoxin + NADP
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Bos taurus oxidized adrenodoxin + NADPH + H+
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?

Synonyms

Synonyms Comment Organism
AdR
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Bos taurus
adrenodoxin reductase
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Bos taurus
NADPH:adrenodoxin reductase
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Bos taurus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Bos taurus

General Information

General Information Comment Organism
metabolism the enzyme functions in the mitochondrial electron transport chain for cytochrome P450-dependent steroid hydroxylation by donating the electrons to adrenodoxin which further transfers them to cytochromes P450scc or P4511beta Bos taurus