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Literature summary for 1.17.7.4 extracted from

  • Hsieh, W.Y.; Sung, T.Y.; Wang, H.T.; Hsieh, M.H.
    Functional evidence for the critical amino-terminal conserved domain and key amino acids of Arabidopsis 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (2014), Plant Physiol., 166, 57-69.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information construction of genomic HDR transgene-induced gene-silencing lines showing an albino, variegated, or pale green phenotype, overview. The cotyledons of T4 seedlings are pale green, light yellow, or albino, indicating that the bleaching phenotype of these lines occurs earlier and is more severe than in previous generations Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
Arabidopsis thaliana 9507
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q94B35 gene ispH, single-copy gene
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Arabidopsis thaliana
-

Synonyms

Synonyms Comment Organism
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
-
Arabidopsis thaliana

General Information

General Information Comment Organism
evolution the structure and reaction mechanism of HDR evolution have become specific for oxygen-evolving photosynthesis organisms and that enzyme HDR probably evolved independently in cyanobacteria versus other prokaryotes Arabidopsis thaliana
malfunction construction of genomic HDR transgene-induced gene-silencing lines showing an albino, variegated, or pale green phenotype, confirming that HDR is essential for plants Arabidopsis thaliana
additional information homology modeling using Escherichia coli isoprenoid synthesis H, PDB ID 3F7T, as a template. Residues Cys122, Cys213, and Cys350 are involved in iron-sulfur cluster formation and His152, His241, Glu242, Glu243, Thr244, Thr312, Ser379, and Asp381 are related to substrate binding or catalysis Arabidopsis thaliana
physiological function enzyme HDR is essential for plants Arabidopsis thaliana